N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology

JR Moffett, B Ross, P Arun, CN Madhavarao… - Progress in …, 2007 - Elsevier
The brain is unique among organs in many respects, including its mechanisms of lipid
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …

Rapid optofluidic detection of biomarkers for traumatic brain injury via surface-enhanced Raman spectroscopy

JJS Rickard, V Di-Pietro, DJ Smith, DJ Davies… - Nature biomedical …, 2020 - nature.com
Current technologies for the point-of-care diagnosis of traumatic brain injury (TBI) lack
sensitivity, require specialist handling or involve complicated and costly procedures. Here …

Large animal stroke models vs. rodent stroke models, pros and cons, and combination?

B Cai, N Wang - Brain Edema XVI: Translate Basic Science into Clinical …, 2016 - Springer
Stroke is a leading cause of serious long-term disability worldwide and the second leading
cause of death in many countries. Long-time attempts to salvage dying neurons via various …

Local and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance …

UV Wesley, VJ Bhute, JF Hatcher, SP Palecek… - Neurochemistry …, 2019 - Elsevier
Metabolic dysfunction impacts stroke incidence and outcome. However, the intricate
association between altered metabolic program due to aging, and focal ischemia in brain …

Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain

H Lei, C Berthet, L Hirt… - Journal of Cerebral Blood …, 2009 - journals.sagepub.com
Evolution of the neurochemical profile consisting of 19 metabolites after 30 mins of middle
cerebral artery occlusion was longitudinally assessed at 3, 8 and 24 h in 6 to 8 µL volumes …

Temporal evolution of ischemic lesions in nonhuman primates: a diffusion and perfusion MRI study

X Zhang, F Tong, CX Li, Y Yan, D Kempf, G Nair… - PLoS one, 2015 - journals.plos.org
Background and Purpose Diffusion-weighted imaging (DWI) and perfusion MRI were used
to examine the spatiotemporal evolution of stroke lesions in adult macaques with ischemic …

Regulation of Mct1 by cAMP-dependent internalization in rat brain endothelial cells

JP Smith, AL Uhernik, L Li, Z Liu, LR Drewes - Brain research, 2012 - Elsevier
In the cerebrovascular endothelium, monocarboxylic acid transporter 1 (Mct1) controls blood–
brain transport of short chain monocarboxylic and keto acids, including pyruvate and lactate …

Improved reproducibility of MRS regional brain thermometry by 'amplitude‐weighted combination'

EB Cady, J Penrice, NJ Robertson - NMR in Biomedicine, 2011 - Wiley Online Library
Brain temperature is important in stroke and trauma. In birth asphyxia, hypothermia improves
outcome, but local brain temperature information is needed to optimise therapy. The proton …

Regulation of monocarboxylic acid transporter 1 trafficking by the canonical Wnt/β-catenin pathway in rat brain endothelial cells requires cross-talk with Notch …

Z Liu, M Sneve, TA Haroldson, JP Smith… - Journal of Biological …, 2016 - ASBMB
The transport of monocarboxylate fuels such as lactate, pyruvate, and ketone bodies across
brain endothelial cells is mediated by monocarboxylic acid transporter 1 (MCT1). Although …

[PDF][PDF] Применение сукцинатов для коррекции метаболических нарушений в зоне ишемической полутени у пациентов с инсультом

ММ Одинак, СН Янищевский, НВ Цыган - Журнал неврологии и …, 2013 - mexidol.ru
Цель работы—определение методом МР-спектроскопии количественного содержания
и соотношения различных метаболитов в ядре инфаркта, ишемической полутени и …