Alexander disease is a rare and generally fatal disorder of the central nervous system,
originally defined by the distinctive neuropathology consisting of abundant Rosenthal fibers …

In recent years, the scientific and therapeutic fields for rare, genetic central nervous system
(CNS) diseases such as leukodystrophies, or white matter disorders, have expanded …

Introduction: Alexander disease (AxD) is a rare neurodegenerative condition that represents
the group of leukodystrophies. The disease is caused by GFAP mutation. Symptoms usually …

Alexander disease (AxD) is a rare, autosomal dominant neurological disorder. Three clinical
subtypes are distinguished based on age at onset: infantile (0–2 years), juvenile (2–13 …

The indication for fetal magnetic resonance imaging (MRI) remains a subject of debate,
partly because of questions concerning its diagnostic accuracy compared to ultrasound …

Abstract Objectives Alexander disease (AxD) is a rare autosomal dominant disorder due to
GFAP mutations; infantile AxD is the most common severe form which usually results in …

Alexander disease is a leukodystrophy caused by dominant missense mutations in the gene
encoding the glial fibrillary acidic protein. Individuals with this disorder often present with a …

Alexander disease (AxD) is a genetic leukodystrophy caused by GFAP mutations leading to
astrocyte dysfunction. Neonatal AxD is a rare phenotype with onset in the first month of life …

Alexander disease is a leukodystrophy caused by mutations in the GFAP gene, primarily
affecting the astrocytes. This report describes the prenatal and post-mortem neuroimaging …

Introduction Alexander disease is a disorder caused by a mutation and accumulation of the
glial fibrillary acidic protein. Currently, three subtypes are acknowledged: an infantile, a …