Baclofen is an effective therapeutic for the treatment of spasticity related to multiple sclerosis,
spinal cord injuries, and other spinal cord pathologies. It has been increasingly used off …

Chronic diseases account for the majority of all deaths worldwide, and their prevalence is
expected to escalate in the next 10 years. Because chronic disorders require long-term …

Introduction Intrathecal therapy is an important part of the pain treatment algorithm for
chronic disease states. The use of this option is a viable treatment strategy, but it is inherent …

Object This single-center study investigated adverse events that occurred in children and
adolescent patients treated with intrathecal baclofen (ITB) therapy for spasticity and/or …

Introduction Troubleshooting helps optimize intrathecal baclofen (ITB) therapy in cases of
underdose, overdose, and infection. Methods An expert panel of 21 multidisciplinary …

There are nearly 1.8 million annual emergency room visits and over 289,000 annual
hospitalizations related to traumatic brain injury (TBI). The goal of this review article is to …

Background: Intrathecal baclofen (ITB) delivered by programmable pump devices
represents an important modality for long-term treatment of severe spinal spasticity …

OBJECTIVE In this single-center study the authors investigated the complications occurring
before and after the introduction of the new Ascenda intrathecal catheter (Medtronic Inc.) in …

We prepared an implantable device of small volume (SID) that is enabled with on-demand,
pulsatile drug release. The device was designed to be actuated via a magnetic field; hence …

Muscle spasms and spasticity constitute a significant problem in patients with spinal cord
injury, interfering with rehabilitation and leading to impairments in quality of life in addition to …