[HTML][HTML] Fixel-based analysis of diffusion MRI: methods, applications, challenges and opportunities

T Dhollander, A Clemente, M Singh, F Boonstra… - Neuroimage, 2021 - Elsevier
Diffusion MRI has provided the neuroimaging community with a powerful tool to acquire in-
vivo data sensitive to microstructural features of white matter, up to 3 orders of magnitude …

Traumatic brain injuries

K Blennow, DL Brody, PM Kochanek, H Levin… - Nature reviews Disease …, 2016 - nature.com
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI

P Shahim, A Politis, A Van Der Merwe, B Moore… - Neurology, 2020 - AAN Enterprises
Objective To determine whether neurofilament light (NfL), glial fibrillary acidic protein
(GFAP), tau, and ubiquitin C-terminal hydrolase-L1 (UCH-L1) measured in serum relate to …

Post-traumatic headache: epidemiology and pathophysiological insights

H Ashina, F Porreca, T Anderson, FM Amin… - Nature Reviews …, 2019 - nature.com
Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one
of the most common sequelae of mild traumatic brain injury, also known as concussion …

Neurofilament light as a biomarker in traumatic brain injury

P Shahim, A Politis, A Van Der Merwe, B Moore… - Neurology, 2020 - AAN Enterprises
Objective To determine whether serum neurofilament light (NfL) correlates with CSF NfL,
traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor …

Aging of cerebral white matter

H Liu, Y Yang, Y Xia, W Zhu, RK Leak, Z Wei… - Ageing research …, 2017 - Elsevier
White matter (WM) occupies a large volume of the human cerebrum and is mainly composed
of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are …

Neuropsychology of traumatic brain injury: An expert overview

P Azouvi, A Arnould, E Dromer, C Vallat-Azouvi - Revue neurologique, 2017 - Elsevier
Traumatic brain injury (TBI) is a serious healthcare problem, and this report is a selective
review of recent findings on the epidemiology, pathophysiology and neuropsychological …

Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brain

D Benjamini, D Iacono, ME Komlosh, DP Perl… - Brain, 2021 - academic.oup.com
Axonal injury is a major contributor to the clinical symptomatology in patients with traumatic
brain injury. Conventional neuroradiological tools, such as CT and MRI, are insensitive to …

Imaging evidence and recommendations for traumatic brain injury: conventional neuroimaging techniques

M Wintermark, PC Sanelli, Y Anzai, AJ Tsiouris… - Journal of the American …, 2015 - Elsevier
Imaging plays an essential role in identifying intracranial injury in patients with traumatic
brain injury (TBI). The goals of imaging include (1) detecting injuries that may require …

Traumatic brain injury as a disorder of brain connectivity

JP Hayes, ED Bigler, M Verfaellie - Journal of the International …, 2016 - cambridge.org
Objectives: Recent advances in neuroimaging methodologies sensitive to axonal injury
have made it possible to assess in vivo the extent of traumatic brain injury (TBI)-related …