In patients with schizophrenia neuroimaging studies have revealed global differences with
some brain regions showing focal abnormalities. Examining neurocircuitry, diffusion …

Schizophrenia is a debilitating psychiatric disorder characterized by positive, negative and
cognitive symptoms. Despite more than a century of research, the neurobiological …

Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

Background The cognitive deficits of schizophrenia are largely resistant to current treatments
and thus are a lifelong illness burden. The Measurement and Treatment Research to …

Schizophrenia has long been hypothesized to result from a disconnection syndrome due to
a disruption of the association fibers of the brain. However, only with the advent of in vivo …

BackgroundSchizophrenia (SCZ) and psychotic bipolar disorder (PBD) share considerable
overlap in clinical features, genetic risk factors and co-occurrence among relatives. The …

The last two decades have seen a re-emergence of neurosurgery for severe, refractory
psychiatric diseases, largely due to the advent of more precise and safe operative …

It is becoming increasingly clear that longer duration of untreated psychosis (DUP) is
associated with adverse clinical outcomes in patients with psychosis spectrum disorders …

Duration of untreated psychosis (DUP) is defined as the time from the onset of psychotic
symptoms until the first treatment. Studies have shown that longer DUP is associated with …

Background Abnormal white matter integrity has been reported among first episode
schizophrenia patients. However, findings on whether it can be reversed by short-term …