Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Importance Stroke is the second leading cause of death in the world, and nearly one-third of
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …

Objective To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF
pulsatility, and their independent relationship with cerebral small vessel disease (SVD) …

Cerebral small vessel diseases (SVDs) are a leading cause of age and hypertension-related
stroke and dementia. The salient features of SVDs visible on conventional brain magnetic …

Since the term “lacune” was adopted in the 1800s to describe infarctions from cerebral small
vessels, their underlying pathophysiological basis remained obscure until the 1960s when …

Leukoaraiosis (LA) refers to white matter hyperintensities or white matter lesions (WMLs) on
magnetic resonance imaging (MRI) scans of the brain; this disease is associated with an …

White matter lesions have been implicated in the setting of stroke, dementia, intracerebral
haemorrhage, several other cerebrovascular conditions, migraine, various …

The pathophysiology of lacunar infarction is an evolving and debated field, where relevant
information comes from histopathology, old anatomical studies and animal models. Only in …

White matter hyperintensities (WMHs) of presumed vascular origin are one of the imaging
markers of cerebral small-vessel disease, which is prevalent in older individuals and closely …

The brain is a neurovascular organ. A stimulus-response approach is effective in
interrogating the physiology of its vasculature. Ideally, the stimulus is standardized across …