Proton magnetic resonance spectroscopy of N-acetyl aspartate in chronic schizophrenia, first episode of psychosis and high-risk of psychosis: a systematic review and …

TS Whitehurst, M Osugo, L Townsend… - Neuroscience & …, 2020 - Elsevier
Abstract N-acetyl-aspartate (NAA) is a readily measured marker of neuronal metabolism.
Previous analyses in schizophrenia have shown NAA levels are low in frontal, temporal and …

[HTML][HTML] NMDA receptor model of antipsychotic drug-induced hypofrontality

M Krzystanek, A Pałasz - International Journal of Molecular Sciences, 2019 - mdpi.com
Schizophrenia is a chronic mental disease, affecting around 1% of the general population.
Schizophrenia is characterized by productive, negative, affective, and disorganization …

Gut and oral microbiome modulate molecular and clinical markers of schizophrenia-related symptoms: a transdiagnostic, multilevel pilot study

JJ Lee, E Piras, S Tamburini, K Bu, DS Wallach… - Psychiatry …, 2023 - Elsevier
Although increasing evidence links microbial dysbiosis with the risk for psychiatric symptoms
through the microbiome-gut-brain axis (MGBA), the specific mechanisms remain poorly …

Association of hippocampal glutamate levels with adverse outcomes in individuals at clinical high risk for psychosis

MG Bossong, M Antoniades, M Azis, C Samson… - JAMA …, 2019 - jamanetwork.com
Importance Preclinical and human data suggest that hippocampal dysfunction plays a
critical role in the onset of psychosis. Neural hyperactivity in the hippocampus is thought to …

The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group

BL Bartnik-Olson, JR Alger, T Babikian… - Brain imaging and …, 2021 - Springer
Proton (1 H) magnetic resonance spectroscopy provides a non-invasive and quantitative
measure of brain metabolites. Traumatic brain injury impacts cerebral metabolism and a …

An integrative study of the microbiome gut-brain-axis and hippocampal inflammation in psychosis: persistent effects from mode of birth

P Joe, JC Clemente, E Piras, DS Wallach… - Schizophrenia …, 2022 - Elsevier
The mechanism producing psychosis appears to include hippocampal inflammation, which
could be associated with the microbiome-gut-brain-axis (MGBS). To test this hypothesis we …

[HTML][HTML] Study of the hippocampal internal architecture in temporal lobe epilepsy using 7 T and 3 T MRI

Y Zhang, Y Lv, H You, W Dou, B Hou, L Shi, Z Zuo… - Seizure, 2019 - Elsevier
Purpose To compare the hippocampal internal architecture (HIA) between 3 and 7 Tesla (T)
magnetic resonance imaging (MRI) in patients with temporal lobe epilepsy (TLE), and to …

Glutamatergic hypo-function in the left superior and middle temporal gyri in early schizophrenia: a data-driven three-dimensional proton spectroscopic imaging study

JR Bustillo, J Upston, EG Mayer, T Jones… - …, 2020 - nature.com
Proton magnetic resonance spectroscopy (1H-MRS) studies have examined glutamatergic
abnormalities in schizophrenia, mostly in single voxels. Though the critical brain nodes …

[HTML][HTML] Metabolic heterogeneity in different subtypes of malformations of cortical development causing epilepsy: a proton magnetic resonance spectroscopy study

H Pu, L Wang, W Liu, Q Tan, X Wan… - … Imaging in Medicine …, 2023 - ncbi.nlm.nih.gov
Background The most common subtypes of malformations of cortical development (MCDs)
are gray matter heterotopia (GMH), focal cortical dysplasia (FCD), and polymicrogyria …

Preliminary Findings Associate Hippocampal 1H-MR Spectroscopic Metabolite Concentrations with Psychotic and Manic Symptoms in Patients with Schizophrenia

D Malaspina, E Lotan, H Rusinek… - American Journal …, 2021 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Previous hippocampal proton MR spectroscopic imaging
distinguished patients with schizophrenia from controls by elevated Cr levels and …