Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

MD Hill, M Goyal, BK Menon, RG Nogueira… - The Lancet, 2020 - thelancet.com
Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia …

European Stroke Organisation (ESO) guidelines on management of transient ischaemic attack

AC Fonseca, A Merwick, M Dennis… - European Stroke …, 2021 - journals.sagepub.com
The aim of the present European Stroke Organisation Transient Ischaemic Attack (TIA)
management guideline document is to provide clinically useful evidence-based …

Kaempferol protects against cerebral ischemia reperfusion injury through intervening oxidative and inflammatory stress induced apoptosis

J Wang, J Mao, R Wang, S Li, B Wu… - Frontiers in …, 2020 - frontiersin.org
The aim of this research is to investigate the potential neuro-protective effect of kaempferol
which with anti-oxidant, anti-inflammatory, and immune modulatory properties, and …

Evolving treatments for acute ischemic stroke

C Zerna, J Hegedus, MD Hill - Circulation research, 2016 - Am Heart Assoc
The purpose of this article is to review advances in stroke treatment in the hyperacute
period. With recent evolutions of technology in the fields of imaging, thrombectomy devices …

Recent developments in pre-hospital and in-hospital triage for endovascular stroke treatment

JM Ospel, AA Dmytriw, RW Regenhardt… - Journal of …, 2023 - jnis.bmj.com
Triage describes the assignment of resources based on where they can be best used, are
most needed, or are most likely to achieve success. Triage is of particular importance in time …

Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times: A Cluster Randomized Clinical Trial

JC Martinez-Gutierrez, Y Kim, S Salazar-Marioni… - JAMA …, 2023 - jamanetwork.com
Importance The benefit of endovascular stroke therapy (EVT) in large vessel occlusion
(LVO) ischemic stroke is highly time dependent. Process improvements to accelerate in …

Multiphase CT angiography increases detection of anterior circulation intracranial occlusion

AYX Yu, C Zerna, Z Assis, JK Holodinsky… - Neurology, 2016 - AAN Enterprises
Objective: To evaluate whether the use of multiphase CT angiography (CTA) improves
interrater agreement for intracranial occlusion detection between stroke neurology trainees …

Deep learning-based identification of acute ischemic core and deficit from non-contrast CT and CTA

C Wang, Z Shi, M Yang, L Huang… - Journal of Cerebral …, 2021 - journals.sagepub.com
The accurate identification of irreversible infarction and salvageable tissue is important in
planning the treatments for acute ischemic stroke (AIS) patients. Computed tomographic …

Components and trends in door to treatment times for endovascular therapy in get with the guidelines-stroke hospitals

BK Menon, H Xu, M Cox, JL Saver, M Goyal… - Circulation, 2019 - Am Heart Assoc
Background: Endovascular therapy (EVT) is standard of care in patients with acute disabling
ischemic stroke attributable to large-vessel occlusion and is more effective when delivered …

Emergency department door-to-puncture time since 2014: observations from the BEST-MSU study

AL Czap, JC Grotta, SA Parker, JM Yamal, R Bowry… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—The impact of a mobile stroke unit (MSU) on access to
intraarterial thrombectomy (IAT) is a prespecified BEST-MSU substudy (Benefits of Stroke …