The spinal cord is frequently affected in multiple sclerosis (MS), causing motor, sensory and
autonomic dysfunction. A number of pathological abnormalities, including demyelination …

The recently developed effective treatment of primary progressive multiple sclerosis (PPMS)
requires the accurate diagnosis of patients with this type of disease. Currently, the diagnosis …

Objective Spinal cord atrophy is a clinically relevant feature of multiple sclerosis (MS), but
longitudinal assessments on magnetic resonance imaging using segmentation‐based …

Background: Little is known on longer term changes of spinal cord volume (SCV) in primary
progressive multiple sclerosis (PPMS). Objective: Longitudinal evaluation of SCV loss in …

Objective To characterize the distribution and regional evolution of cervical cord atrophy in
patients with multiple sclerosis (MS) in a multicenter dataset. Methods MRI and clinical …

Objective We sought to characterize spinal cord atrophy along the entire spinal cord in the
major multiple sclerosis (MS) phenotypes, and evaluate its correlation with clinical disability …

Background In vivo quantification of spinal cord atrophy in neurological diseases using MRI
has attracted increasing attention. Purpose To compare across different platforms the most …

Multiple sclerosis (MS) is a common inflammatory, demyelinating and degenerative disease
of the central nervous system. The majority of people with MS present with symptoms due to …

ABSTRACT BACKGROUND AND PURPOSE Although global and regional brain volume
has been established as a relevant measure to define and predict multiple sclerosis (MS) …

Background We aimed to evaluate the implications for clinical trial design of the generalised
boundary-shift integral (GBSI) for spinal cord atrophy measurement. Methods We included …