Quantitative susceptibility mapping (QSM), one of the advanced MRI techniques for
evaluating magnetic susceptibility, offers precise quantitative measurements of spatial …

Quantitative susceptibility mapping (QSM) has gained broad interest in the field by extracting
bulk tissue magnetic susceptibility, predominantly determined by myelin, iron and calcium …

Recent data suggest that multiple sclerosis white matter lesions surrounded by a rim of iron
containing microglia, termed iron rim lesions, signify patients with more severe disease …

Background and Objectives To determine the effects of dimethyl fumarate (DMF) and
glatiramer acetate on iron content in chronic active lesions in patients with multiple sclerosis …

Quantitative susceptibility mapping (QSM) is a novel magnetic resonance imaging (MRI)
technique for quantifying the spatial distribution of magnetic susceptibility within an object or …

Chronic active lesions (CAL) are an important manifestation of chronic inflammation in
multiple sclerosis (MS) and have implications for non-relapsing biological progression. In …

Background: Paramagnetic rims have been observed as a feature of some multiple sclerosis
(MS) lesions on susceptibility-sensitive magnetic resonance imaging (MRI) and indicate …

Background Inflammation in chronic active lesions occurs behind a closed blood–brain
barrier and cannot be detected with MRI. Activated microglia are highly enriched for iron and …

Background Chronic active lesions (CAL) in multiple sclerosis (MS) have been observed
even in patients taking high-efficacy disease-modifying therapy, including B-cell depletion …

Focal lesions in both white and gray matter are characteristic of multiple sclerosis (MS).
Histopathological studies have helped define the main underlying pathological processes …