Targeted anticancer drugs block cancer cell growth by interfering with specific signaling
pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing …

Neuroimaging plays a central role but still often falls short on essential questions. Advanced
imaging acquisition and analysis techniques hold great promise for answering such …

Abstract Background In Radiation Therapy Oncology Group (RTOG) 0825, a phase III trial of
standard therapy with bevacizumab or without (placebo) in newly diagnosed glioblastoma …

Background and Purpose Fractional tumor burden better correlates with histologic tumor
volume fraction in treated glioblastoma than other perfusion metrics such as relative CBV …

Background Brain tumor therapeutic responses can be quantified from magnetic resonance
images (MRI) using 1‐(1D) and 2‐dimensional (2D) linear and volumetric methods, but few …

Background: Progressive enhancement predicted poor survival in ACRIN 6677/RTOG 0625,
a multi-center trial of bevacizumab with irinotecan or temozolomide in recurrent …

Background Treatment-resistant glioblastoma (trGBM) is an aggressive brain tumor with a
dismal prognosis, underscoring the need for better treatment options. Emerging data …

Perfusion imaging is of great clinical importance and is used to assess a wide range of
diseases including strokes and brain tumors. Commonly used approaches for the …

Advection-diffusion equations describe a large family of natural transport processes, eg, fluid
flow, heat transfer, and wind transport. They are also used for optical flow and perfusion …

Relative cerebral blood volume (rCBV) derived from dynamic susceptibility contrast (DSC)
perfusion MR imaging (pMRI) has been shown to be a robust marker of neuroradiological …