Current understanding of macrophages in intracranial aneurysm: relevant etiological manifestations, signaling modulation and therapeutic strategies

J Duan, Q Zhao, Z He, S Tang, J Duan… - Frontiers in …, 2024 - frontiersin.org
Macrophages activation and inflammatory response play crucial roles in intracranial
aneurysm (IA) formation and progression. The outcome of ruptured IA is considerably poor …

Macrophage activation in response to shape memory polymer f oam‐coated aneurysm occlusion devices

SM Chau, SM Herting, DA Noltensmeyer… - … Research Part B …, 2022 - Wiley Online Library
Brain aneurysms can be treated with embolic coils using minimally invasive approaches. It is
advantageous to modulate the biologic response of platinum embolic coils. Our previous …

Degrees of macrophage‐facilitated healing in aneurysm occlusion devices

DA Donehoo, CA Collier… - … Research Part B …, 2024 - Wiley Online Library
Insufficient healing of aneurysms following treatment with vascular occlusion devices put
patients at severe risk of fatal rupture. Therefore, promoting healing and not just occlusion is …

Elucidating key immunological biomarkers and immune microenvironment dynamics in aging‐related intracranial aneurysm through integrated multi‐omics analysis

K Wang, Y Xiao, W Zhang, H Yang, C Li… - Environmental …, 2024 - Wiley Online Library
Background The exact cause of intracranial aneurysms (IA) is still unclear. However, pro‐
inflammatory factors are known to contribute to IA progression. The specific changes in the …

Macrophage Migration Inhibitory Factor (MIF) Axis Drives Intracranial Aneurysms Macrophage M1 Polarization: Insights from Single-Cell and Bulk RNA Sequencing

J Huang, Y Chen, Y Kang, J Song - 2024 - researchsquare.com
Background: Intracranial aneurysms (IAs) develop and progress through pathological
processes, including inflammation and abnormal changes in the vascular structure. The …