Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

M Jakaria, AA Belaidi, AI Bush… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury

M Farina, DS Avila, JBT Da Rocha… - Neurochemistry …, 2013 - Elsevier
Essential metals are crucial for the maintenance of cell homeostasis. Among the 23
elements that have known physiological functions in humans, 12 are metals, including iron …

Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis

T Rui, H Wang, Q Li, Y Cheng, Y Gao… - Journal of Pineal …, 2021 - Wiley Online Library
Accumulating evidence demonstrates that ferroptosis may be important in the
pathophysiological process of traumatic brain injury (TBI). As a major hormone of the pineal …

[HTML][HTML] Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

QS Li, YJ Jia - Neural Regeneration Research, 2023 - journals.lww.com
Ferroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-
dependent phospholipid peroxidation. Ferroptosis plays a key role in secondary traumatic …

[HTML][HTML] The role of iron, its metabolism and ferroptosis in traumatic brain injury

S Tang, P Gao, H Chen, X Zhou, Y Ou… - Frontiers in cellular …, 2020 - frontiersin.org
Traumatic brain injury (TBI) is a structural and physiological disruption of brain function
caused by external forces. It is a major cause of death and disability for patients worldwide …

Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects

FH Kobeissy - 2015 - books.google.com
Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities
impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result …

Mild traumatic brain injury: longitudinal regional brain volume changes

Y Zhou, A Kierans, D Kenul, Y Ge, J Rath, J Reaume… - Radiology, 2013 - pubs.rsna.org
Purpose To investigate longitudinal changes in global and regional brain volume in patients
1 year after mild traumatic brain injury (MTBI) and to correlate such changes with clinical and …

[HTML][HTML] Single cell molecular alterations reveal target cells and pathways of concussive brain injury

D Arneson, G Zhang, Z Ying, Y Zhuang… - Nature …, 2018 - nature.com
The complex neuropathology of traumatic brain injury (TBI) is difficult to dissect, given the
convoluted cytoarchitecture of affected brain regions such as the hippocampus …

[HTML][HTML] Ferroptosis: an iron-dependent cell death form linking metabolism, diseases, immune cell and targeted therapy

S Li, Y Huang - Clinical and Translational Oncology, 2022 - Springer
Compared with the traditional forms of cell death—apoptosis, necrosis and autophagy,
ferroptosis is a novel form of iron-dependent programmed cell death forms which is different …

Neuroimaging biomarkers in mild traumatic brain injury (mTBI)

ED Bigler - Neuropsychology review, 2013 - Springer
Reviewed herein are contemporary neuroimaging methods that detect abnormalities
associated with mild traumatic brain injury (mTBI). Despite advances in demonstrating …