[HTML][HTML] Evidence for infection in intervertebral disc degeneration: a systematic review

I Granville Smith, NP Danckert, MB Freidin… - European Spine …, 2022 - Springer
Purpose Back pain is a major problem worldwide and is linked to intervertebral disc
degeneration and Modic change. Several studies report growth of bacteria following …

[HTML][HTML] A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human …

MN Capoor, C Birkenmaier, JC Wang… - European Spine …, 2019 - Springer
Purpose Recent research shows an increasing recognition that organisms not traditionally
considered infectious in nature contribute to disease processes. Propionibacterium acnes …

[HTML][HTML] Would Cutibacterium acnes Be the Villain for the Chronicity of Low Back Pain in Degenerative Disc Disease? Preliminary Results of an Analytical Cohort

VM da Rocha, COGX Lima, GB Candido… - Journal of personalized …, 2023 - mdpi.com
In the last decade, several studies have demonstrated Cutibacterium acnes colonization in
intervertebral discs (IVDs) in patients with lumbar disc degeneration (LDD) and low back …

[HTML][HTML] Pro-inflammatory and neurotrophic factor responses of cells derived from degenerative human intervertebral discs to the opportunistic pathogen …

MN Capoor, A Konieczna, A McDowell… - International Journal of …, 2021 - mdpi.com
Previously, we proposed the hypothesis that similarities in the inflammatory response
observed in acne vulgaris and degenerative disc disease (DDD), especially the central role …

[HTML][HTML] Modic change is associated with increased BMI but not autoimmune diseases in TwinsUK

F Gualdi, IG Smith, RC Boixader, FMK Williams - European Spine Journal, 2023 - Springer
Purpose Low back pain (LBP) is one of the largest causes of morbidity worldwide. The
aetiology of LBP is complex, and many factors contribute to the onset. Bone marrow lesions …

Early adherence and biofilm formation of Cutibacterium acnes (formerly Propionibacterium acnes) on spinal implant materials

D Garcia, CK Mayfield, J Leong, DG Deckey, A Zega… - The Spine Journal, 2020 - Elsevier
BACKGROUND Cutibacterium acnes (C. acnes) is associated with infection following
shoulder and spine surgery due to follicular pore concentrations in these anatomic regions …

[HTML][HTML] Frequency and characteristics of bacterial and viral low-grade infections of the intervertebral discs: a prospective, observational study

W Senker, S Aspalter, C Radl, J Pichler… - Journal of Orthopaedics …, 2022 - Springer
Study design Monocentric, prospective, observational study. Objective The clinical
relevance of bacterial colonization of intervertebral discs is controversial. This study aimed …

[HTML][HTML] Induction of cervical disc degeneration and discogenic pain by low concentration Propionibacterium acnes infection: an in vivo animal study

J Li, H Li, Y Chen, D Bei, B Huang, K Gan… - Arthritis Research & …, 2024 - Springer
Background Although cervical intervertebral disc (IVD) degeneration is closely associated
with neck pain, its cause remains unclear. In this study, an animal model of cervical disc …

[HTML][HTML] Modic changes of the lumbar spine—their association with the lumbar sagittal parameters: A retrospective imaging study

X Mu, W Peng, C Yu, J Xiong, J Wei, Y Ou… - Journal of Orthopaedic …, 2020 - Springer
Abstract Background The Lumbar sagittal parameters might be related to modic changes
(MCs). However, studies on this topic have rarely been reported. The aim of this study was to …

Different responses of cervical intervertebral disc caused by low and high virulence bacterial infection: a comparative study in rats

J Li, Y Chen, H Wu, Z Shan, D Bei, K Gan, J Liu… - …, 2022 - Taylor & Francis
The aims of this study were to investigate the outcomes of low-and high-virulence bacterial
cervical intervertebral discs (IVDs) infection and its association with cervical IVDs …