BACKGROUND AND PURPOSE: Three families with adult-onset autosomal dominant
leukodystrophy (ADLD) presenting autonomic dysfunction as the first symptom are reported …

BACKGROUND AND PURPOSE: MR imaging findings in adult-onset autosomal dominant
leukodystrophy (ADLD) with autonomic symptoms have been described in the brain, but no …

We report MRI findings in a family with an autosomal-dominant, adult-onset neurological
disorder. The clinical picture, the white matter changes detected on MRI and the absence of …

Objective: To study the clinical and pathological features of a kindred with an adult-onset
autosomal dominant leukodystrophy. Patients: Five symptomatic and nine asymptomatic at …

We report here a family with leukodystrophy clinical features of which are characterized as
adult onset, probably autosomal dominant inheritance, hyperreflexia, cerebellar ataxia …

We studied a large kindred with a chronic progressive neurologic disorder affecting at least
10 men and 11 women in four generations in a pattern compatible with autosomal dominant …

Background: Among hereditary leukodystrophies, a considerable number remain
unclassified. Patient and results: We investigated the clinical course and histopathology of …

• Five clinically affected and nine atrisk members of a kindred with an autosomal dominant
adult-onset leukodystrophy simulating chronic progressive multiple sclerosis were studied …

Adult-onset autosomal dominant leukodystrophy (ADLD) was first described for a large
kindred with a progressive and fatal neurological white matter disorder in an American-Irish …

Autosomal dominant leukodystrophy (ADLD) with autonomic symptoms is a slowly
progressive leukodystrophy with an onset in the 4th to 6th decade of life. Early symptoms are …