Spatial correlation of pathology and perfusion changes within the cortex and white matter in multiple sclerosis

AD Mulholland, R Vitorino, SP Hojjat… - American Journal …, 2018 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The spatial correlation between WM and cortical GM
disease in multiple sclerosis is controversial and has not been previously assessed with …

The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis

CM Holland, A Charil, I Csapo, Z Liptak… - Journal of …, 2012 - Wiley Online Library
ABSTRACT BACKGROUND AND PURPOSE The pathological differences underlying the
clinical disease phases in multiple sclerosis (MS) are poorly characterized. We sought to …

Cortical perfusion alteration in normal-appearing gray matter is most sensitive to disease progression in relapsing-remitting multiple sclerosis

SP Hojjat, M Kincal, R Vitorino… - American Journal …, 2016 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The role of gray matter in multiple sclerosis is increasingly
evident; however, conventional images demonstrate limitations in cortical lesion …

Robust perfusion deficits in cognitively impaired patients with secondary-progressive multiple sclerosis

PL Francis, R Jakubovic, P O'connor… - American Journal …, 2013 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Cognitive impairment is a common, disabling symptom of
MS. We investigated the impact of cerebral perfusion and brain and lesion volumetry on …

Longitudinal spatiotemporal distribution of gray and white matter pathology in multiple sclerosis

K Bendfeldt, L Kappos, EW Radue… - American Journal of …, 2010 - Am Soc Neuroradiology
We read with great interest the article by Filippi and Rocca entitled “MR Imaging of Gray
Matter Involvement in Multiple Sclerosis: Implications for Understanding Disease …

Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T

M Inglese, SJ Park, G Johnson, JS Babb… - Archives of …, 2007 - jamanetwork.com
Objectives To assess the presence of perfusion abnormalities in the deep gray matter of
patients with relapsing-remitting and primary progressive multiple sclerosis (MS) in …

Correlation of diffusion tensor and dynamic perfusion MR imaging metrics in normal-appearing corpus callosum: support for primary hypoperfusion in multiple …

AM Saindane, M Law, Y Ge… - American Journal …, 2007 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Hypoperfusion of the normal-appearing white matter in
multiple sclerosis (MS) may be related to ischemia or secondary to hypometabolism from …

Pattern of hemodynamic impairment in multiple sclerosis: dynamic susceptibility contrast perfusion MR imaging at 3.0 T

S Adhya, G Johnson, J Herbert, H Jaggi, JS Babb… - Neuroimage, 2006 - Elsevier
This study aimed to determine regional pattern of tissue perfusion in the normal-appearing
white matter (NAWM) of patients with primary-progressive (PP), relapsing-remitting (RR) …

Pathophysiology of multiple sclerosis damage and repair: Linking cerebral hypoperfusion to the development of irreversible tissue loss in multiple sclerosis using …

D Mascali, A Villani, AM Chiarelli… - European journal of …, 2023 - Wiley Online Library
Background and purpose Reduced cerebral perfusion has been observed in multiple
sclerosis (MS) and may contribute to tissue loss both acutely and chronically. Here, we test …

Pathophysiology of MS damage and repair: linking cerebral hypoperfusion to the development of irreversible tissue loss in MS using MRI.

D Mascali, A Villani, AM Chiarelli… - European Journal of …, 2023 - europepmc.org
Reduced cerebral perfusion has been observed in Multiple Sclerosis and may contribute to
tissue loss both acutely and chronically. Here, we test the hypothesis that hypoperfusion …