BACKGROUND AND PURPOSE: Functional MR imaging has been used to study patterns of
hippocampal activation that distinguish pathologic from normal memory loss in the elderly …

Objective: To use functional MRI (fMRI) to investigate whether hippocampal activation during
a memory task can predict cognitive decline in individuals with mild cognitive impairment …

Functional magnetic resonance imaging (fMRI) studies in memory impairment have detected
functional alterations in medial temporal lobe (MTL) structures, notably the hippocampus …

BACKGROUND AND PURPOSE: We applied functional MR imaging with a learning task in
healthy elderly volunteers and in patients with Alzheimer's disease to study brain activation …

Memory function commonly declines in later life. Whether memory decline represents a
disease process or whether it is part of normal aging remains unknown. Here we answer this …

Hippocampal atrophy has been related to mild cognitive impairment (MCI) and early
Alzheimer disease (AD), but the diagnostic significance of cross-sectionally determined …

Functional MRI is an attractive method for studying cognitive task-related and resting-state
patterns of brain activation and connectivity. Since hippocampal dysfunction has been …

BACKGROUND AND PURPOSE: Hippocampus volumetry is a useful surrogate marker for
the diagnosis of Alzheimer disease, but it seems insufficiently sensitive for the aMCI stage …

Abstract Mild Cognitive Impairment (MCI) is considered a transitional stage in the
pathogenesis of Alzheimer's disease; however, not all MCI patients progress to clinically …

Objective: To examine the neural basis of cognitive complaints in healthy older adults in the
absence of memory impairment and to determine whether there are medial temporal lobe …