PURPOSE To determine the neurotoxic potential of gadopentetate dimeglumine in an
animal model that allowed the agent to avoid the blood-brain barrier. Gadopentetate …

PURPOSE Results of a previous report showed that, if administered by intraventricular
injection to access tissue normally protected by the blood-brain barrier, gadopentetate …

J Neurol (2007) 254: 810–812 DOI 10.1007/s00415-006-0439-x delirious state and ataxia,
which we refer to as gadolinum encephalopathy. This term has recently been established by …

Osmotic blood-brain barrier disruption with intraarterial chemotherapy has been shown to be
beneficial in the treatment of malignant brain tumors. Imaging blood-brain barrier disruption …

The intravenous administration of gadopentetate dimeglumine (GD) is relatively safe and
rarely causes systemic toxicity in the course of routine imaging studies. However, the …

Abstract Toney GM, Chavez HA, Ibarra R, et al. Acute and subacute physiological and
histological studies of the central nervous system after intrathecal gadolinium injection in the …

The safety and tolerance of gadopentetate dimeglumine 0.1 mmol/kg when injected at a
bolus rate (10 ml/15 sec; four times the recommended rate) was studied in 12 normal men …

Discussion A severe neurotoxic response after an interthecal or intraventricular injection of
Gd-DTPA has been related to a higher dose in animal models, 13, 14 in which 5–15 μmol/g …

To investigate the safety, patient tolerance, and efficacy with 0.3 mmol/kg gadopentetate
dimeglumine in magnetic resonance (MR) imaging of the central nervous system (CNS), a …

Discussion As the diagnostic value of contrast-enhanced MR imaging has become evident
(3], gadolinium is being used with increased frequency in radiologic practices. Although no …