BACKGROUND AND PURPOSE: Our purpose was to determine the characteristic MR
features of early-onset (before age 2 years) versus late-onset (after age 2 years) globoid cell …

Previous imaging studies in infants with globoid cell leukodystrophy (GLD) using computed
tomography have demonstrated a reduction in cerebral white matter and increased density …

Background Globoid-cell leukodystrophy is caused by a deficiency of galactocerebrosidase,
which results in progressive central nervous system deterioration. We investigated whether …

We examined three autopsy cases of globoid cell leukodystrophy (GLD) with different
survival, using immunohistochemistry and in situ nick end labeling (ISEL). The white matter …

The MR findings in an adult patient with globoid cell leucodystrophy (GLD) or Krabbe's
disease are presented. MRI showed a bilateral periventricular hyperintensity of the parieto …

AMONG the descriptions of cases of globoid cell leucodystrophy there are clinical accounts
of children whose disease has a significantly later onset and slower course {see Table) …

During the past 12 years, ten cases of globoidcell leukodystrophy (GLD) have been followed
up: seven of these patients were affected by the late infantile form. The authors point out the …

The classic globoid cell leukodystrophy (Krabbe's disease) is caused by genetic defects in a
lysosomal enzyme, galactosylceramidase. It is one of the two classic genetic …

We present a patient with adult-onset globoid cell leukodystrophy (GBL) who had almost
complete deficiency of galactosylceramide ß-galactosidase. A brother of the index patient …

Globoid cell leukodystrophy is an autosomal recessive inherited disease caused by
deficiency of the lysosomal enzyme galactocerebrosidase (GALC). Although the severe …