The normal processes of the aging brain remain poorly understood, and some degree of
memory loss is expected in usual senescence. Approximately 10% of the population over …

BACKGROUND AND PURPOSE: Whether Alzheimer disease (AD) represents exaggerated
aging rather than a disease is controversial. Data about the effects of normal aging on the …

IN 1854, MAX DURAND-FARDEL (1816-1899), a keen observer of the peculiar lesions
affecting the brains of the elderly, described interstitial brain atrophy, a condition …

The number of people with dementia worldwide is predicted to increase to 131.5 million by
2050. When studying dementia, understanding the basis of the neuropathological …

We used high-resolution MRI to investigate gray and white matter aging in the major lobes of
the cerebrum (frontal, parietal, temporal, occipital) and the major sectors of the temporal lobe …

The majority of early-onset familial Alzheimer's disease (FAD) is attributed to mutations in
the PS1 gene located on chromosome 14. Recently, increased levels of Aβ ending at …

White matter changes are frequently seen on MRI in elderly patients. The significance of
these changes is still debated. The origin of white matter changes is heterogeneous but the …

Alzheimer's disease (AD) is one of the most common problems for old age people. Etiology
of AD is not clear, but genetic factors play a major role in determining a person's risk to …

Although during the last years significant advances in the research of neurodegenerative
disorders producing dementias have been achieved in their aetiology, clinical and …

Abstract Purpose of Review: This article discusses the recent advances in the diagnosis and
treatment of Alzheimer disease (AD). Recent Findings: In recent years, significant advances …