The topography of brain microstructural damage in amyotrophic lateral sclerosis assessed using diffusion tensor MR imaging

E Canu, F Agosta, N Riva, S Sala… - American journal …, 2011 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: ALS leads to macrostructural (ie, cortical atrophy and
hyperintensities along the corticospinal tract) and microstructural (ie, gray matter intrinsic …

Progressive and widespread brain damage in ALS: MRI voxel-based morphometry and diffusion tensor imaging study

J Senda, S Kato, T Kaga, M Ito, N Atsuta… - Amyotrophic lateral …, 2011 - Taylor & Francis
We investigated 17 patients with sporadic amyotrophic lateral sclerosis (ALS) using voxel-
based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) at …

Assessment of white matter tract damage in patients with amyotrophic lateral sclerosis: a diffusion tensor MR imaging tractography study

F Agosta, E Pagani, M Petrolini… - American Journal …, 2010 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Most DTI studies in ALS have been limited to the
assessment of the CST damage. In this study, we used DTI tractography to investigate …

Diffusion tensor imaging in amyotrophic lateral sclerosis: volumetric analysis of the corticospinal tract

S Wang, H Poptani, M Bilello, X Wu… - American journal …, 2006 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) allows direct visualization
and volumetric analysis of the corticospinal tract (CST). The purpose of this study was to …

Detection of motor cortex thinning and corticospinal tract involvement by quantitative MRI in amyotrophic lateral sclerosis

L Roccatagliata, L Bonzano, G Mancardi… - Amyotrophic Lateral …, 2009 - Taylor & Francis
We prospectively investigated pathological modifications in the corticospinal tract (CST), by
diffusion tensor imaging (DTI) in 14 patients with sporadic amyotrophic lateral sclerosis …

Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis

H Yin, CCT Lim, L Ma, Y Gao, Y Cai, D Li, Y Liang… - Journal of …, 2004 - Springer
Motor neuron damage and cortical spinal tract (CST) degeneration are pathological features
of amyotrophic lateral sclerosis (ALS). We combined whole-brain diffusion tensor imaging …

A longitudinal study of diffusion tensor MRI in ALS

CRV Blain, VC Williams, C Johnston… - Amyotrophic Lateral …, 2007 - Taylor & Francis
In this study, we investigated whether diffusion tensor MRI (DTI) could detect progressive
corticospinal tract degeneration in amyotrophic lateral sclerosis (ALS) and whether changes …

Cognitive functions and white matter tract damage in amyotrophic lateral sclerosis: a diffusion tensor tractography study

L Sarro, F Agosta, E Canu, N Riva… - American Journal …, 2011 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: ALS is predominantly a disease of the motor system, but
cognitive and behavioral symptoms also are observed. DT MR imaging is sensitive to …

Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability

L Thivard, PF Pradat, S Lehéricy… - Journal of Neurology …, 2007 - jnnp.bmj.com
The aim of this study was to investigate the extent of cortical and subcortical lesions in
amyotrophic lateral sclerosis (ALS) using, in combination, voxel based diffusion tensor …

Brain white matter diffusion tensor metrics from clinical 1.5 T MRI distinguish between ALS phenotypes

V Rajagopalan, GH Yue, EP Pioro - Journal of neurology, 2013 - Springer
Patients with amyotrophic lateral sclerosis (ALS) can present with varying degrees of upper
motor neuron (UMN) and lower motor neuron dysfunction. Previous diffusion tensor imaging …