Estimating local cellular density in glioma using MR imaging data

EDH Gates, JS Weinberg, SS Prabhu… - American Journal …, 2021 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Increased cellular density is a hallmark of gliomas, both in
the bulk of the tumor and in areas of tumor infiltration into surrounding brain. Altered cellular …

A multiparametric model for mapping cellularity in glioblastoma using radiographically localized biopsies

PD Chang, HR Malone, SG Bowden… - American Journal …, 2017 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The complex MR imaging appearance of glioblastoma is a
function of underlying histopathologic heterogeneity. A better understanding of these …

Cellular Density in Adult Glioma, Estimated with MR Imaging Data and a Machine Learning Algorithm, Has Prognostic Power Approaching World Health Organization …

EDH Gates, D Suki, A Celaya… - American Journal …, 2022 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Recent advances in machine learning have enabled
image-based prediction of local tissue pathology in gliomas, but the clinical usefulness of …

Multimodal MR imaging model to predict tumor infiltration in patients with gliomas

CR Durst, P Raghavan, ME Shaffrey, D Schiff… - Neuroradiology, 2014 - Springer
Introduction Gliomas remain difficult to treat, in part, due to our inability to accurately
delineate the margins of the tumor. The goal of our study was to evaluate if a combination of …

Radio-pathomic maps of cell density identify brain tumor invasion beyond traditional MRI-defined margins

SA Bobholz, AK Lowman, M Brehler… - American Journal …, 2022 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Currently, contrast-enhancing margins on T1WI are used
to guide treatment of gliomas, yet tumor invasion beyond the contrast-enhancing region is a …

[HTML][HTML] Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology

F Zaccagna, F Riemer, AN Priest, MA McLean… - European …, 2019 - Springer
Purpose This prospective study evaluated the use of vascular, extracellular and restricted
diffusion for cytometry in tumours (VERDICT) MRI to investigate the tissue microstructure in …

Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study

SJ Price, HAL Green, AF Dean… - American journal …, 2011 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: As newer MR imaging techniques are used to assist with
tumor grading, biopsy planning, and therapeutic response assessment, there is a need to …

Accurate patient-specific machine learning models of glioblastoma invasion using transfer learning

LS Hu, H Yoon, JM Eschbacher… - American Journal …, 2019 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: MR imaging–based modeling of tumor cell density can
substantially improve targeted treatment of glioblastoma. Unfortunately, interpatient …

Reliability of tumor volume estimation from MR images in patients with malignant glioma. Results from the American College of Radiology Imaging Network (ACRIN) …

BB Ertl-Wagner, JD Blume, D Peck, JK Udupa… - European …, 2009 - Springer
Reliable assessment of tumor growth in malignant glioma poses a common problem both
clinically and when studying novel therapeutic agents. We aimed to evaluate two software …

Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas

M Kinoshita, H Arita, Y Okita, N Kagawa… - Journal of …, 2016 - thejns.org
OBJECTIVE Diffusion MRI is attracting increasing interest for tissue characterization of
gliomas, especially after the introduction of antiangiogenic therapy to treat malignant …