BACKGROUND AND PURPOSE: In the search for a diagnostic marker in ALS, we focused
our attention on the hyperintense signal intensity in T1 MTC MR images along the CST …

BACKGROUND AND PURPOSE: Hyperintensity in the posterior limb of the internal capsule
at T2-weighted MR imaging, consistent with corticospinal tract (CST) degeneration, is …

The objective of this study was to test the hypothesis that magnetization transfer ratios (MTR)
are decreased in the corticospinal tract of patients with amyotrophic lateral sclerosis (ALS); …

BACKGROUND AND PURPOSE: To date, damage of the cerebral cortex neurons in ALS
was investigated by using conventional MR imaging and proton MR spectroscopy. We …

Diagnosis of amyotrophic lateral sclerosis (ALS) depends on clinical evidence of combined
upper motor neuron (UMN) and lower motor neuron (LMN) degeneration, although ALS …

Purpose To establish the relationship between ALS histopathology and quantitative MRI
metrics. Materials and Methods ALS patients (N= 8) in advanced stages of the disease were …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative system disorder
affecting both upper and lower motor neurons. Despite supportive electrophysiological …

Purpose: To prospectively determine whether diffusion-tensor magnetic resonance (MR)
imaging in conjunction with two-dimensional chemical shift imaging can assist in identifying …

Patients with amyotrophic lateral sclerosis (ALS) can present with varying degrees of upper
motor neuron (UMN) and lower motor neuron dysfunction. Previous diffusion tensor imaging …

The diagnosis of amyotrophic lateral sclerosis (ALS) remains a clinical diagnosis. It is based
on the combination of both upper and lower motor neuron signs in the neurologic …