BACKGROUND AND PURPOSE: Disease activity in normal-appearing white matter
(NAWM) in multiple sclerosis (MS) has been demonstrated in vivo with T1 relaxation time …

Previous studies have established the clinical relevance of hypointense lesions (“black
holes”) on T1-weighted MRI as a surrogate marker for pathological change [36]. In contrast …

Objective To investigate the presence and evolution of T1 relaxation time abnormalities in
normal-appearing white matter (NAWM) and grey matter (GM), early in the course of …

In an attempt to clarify whether T1 relaxation time mapping may assist in characterizing the
pathological brain tissue substrate of multiple sclerosis (MS), we compared the T1 relaxation …

Purpose: To prospectively investigate whether T1 changes in normal-appearing white matter
(WM) and normal-appearing gray matter (GM) in multiple sclerosis (MS) are global or …

BACKGROUND AND PURPOSE: Multiple sclerosis (MS) disease processes in normal-
appearing white matter (NAWM) may be different close to MR-visible lesions than farther …

Quantitative T 1 maps estimate T 1 relaxation times and can be used to assess diffuse tissue
abnormalities within normal-appearing tissue. T 1 maps are popular for studying the …

MRI at 3 T has increased sensitivity in detecting overt multiple sclerosis (MS) brain lesions; a
growing body of data suggests clinically relevant damage occurs in the normal-appearing …

Objective Pathology in multiple sclerosis is not homogenously distributed. Recently, it has
been shown that structures adjacent to CSF are more severely affected. A gradient of brain …

ABSTRACT BACKGROUND AND PURPOSE The pathological differences underlying the
clinical disease phases in multiple sclerosis (MS) are poorly characterized. We sought to …