We read with interest the article by Roosendaal et al 1 about the imaging findings in 132
patients with mitochondrial leukodystrophy. It was concluded that in many of these patients …

BACKGROUND AND PURPOSE: Achieving a specific diagnosis in leukodystrophies is often
difficult due to clinical and genetic heterogeneity. Mitochondrial defects cause 5%–10% of …

Mitochondrial disorders are usually characterized by the combination of deep gray and
white matter involvement on brain imaging. However, a selective white matter involvement …

Objective: To identify patterns of white matter involvement in mitochondrial disease.
Background: Mitochondrial disease has been estimated to affect 1 in 4300 individuals …

Discussion Mitochondrial encephalomyopathies can be divided into three main syndromes
(1): MELAS, myoclonus epilepsy associated with ragged red fibers (MERRF) and Kearns …

Discussion The term mitochondrial encephalomyopathy describes mitochondrial disease in
which both the muscle and the CNS are involved, but, in contrast to mitochondrial myopathy …

Discussion The diagnosis of mitochondrial encephalomyopathy with lactic acidosis and
strokelike episodes (MELAS) syndrome is sometimes elusive owing to the phenomenon of …

ATHIN 50-YEAR-OLD man with a history of diabetes and deafness and a family history of
hearing dysfunction presented with newonset headaches, psychiatric symptoms, and a …

A preterm infantborn at 34 weeks' gestation weighing 1500 g due to intrauterine growth
restriction (IUGR) presented with persistent hyperlacticaemia. Clinical evolution was …

Mitochondrial disease represents a heterogeneous group of genetic disorders that require a
variety of diagnostic tests for proper determination. Neuroimaging may play a significant role …