Dynamic contrast-enhanced MRI reveals unique blood-brain barrier permeability characteristics in the hippocampus in the normal brain

J Ivanidze, M Mackay, A Hoang… - American Journal …, 2019 - Am Soc Neuroradiology
We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific
blood-brain barrier permeability in 5 healthy subjects. By means of standardized …

Vascular volume and blood‐brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal …

H Wang, EJ Golob, MY Su - … Imaging: An Official Journal of the …, 2006 - Wiley Online Library
Purpose To measure the cerebrovascular volume and blood‐brain barrier (BBB)
permeability indices in hippocampus and cerebellum of patients with mild cognitive …

Validation of in vivo magnetic resonance imaging blood–brain barrier permeability measurements by comparison with gold standard histology

A Hoffmann, J Bredno, MF Wendland, N Derugin… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—We sought to validate the blood–brain barrier permeability
measurements extracted from perfusion-weighted MRI through a relatively simple and …

Quantitative measurement of blood‐brain barrier permeability in human using dynamic contrast‐enhanced MRI with fast T1 mapping

S Taheri, C Gasparovic, NJ Shah… - Magnetic resonance …, 2011 - Wiley Online Library
Breakdown of the blood‐brain barrier (BBB), occurring in many neurological diseases, has
been difficult to measure noninvasively in humans. Dynamic contrast‐enhanced magnetic …

Measuring the integrity of the human blood–brain barrier using magnetic resonance imaging

A Kassner, R Thornhill - The Blood-Brain and Other Neural Barriers …, 2011 - Springer
The evaluation of blood–brain barrier (BBB) integrity with contrast-enhanced magnetic
resonance imaging (MRI) may prove valuable in the setting of certain brain pathologies …

Dynamic contrast-enhanced MRI and CT provide comparable measurement of blood–brain barrier permeability in a rodent stroke model

Z Merali, T Wong, J Leung, MMY Gao, D Mikulis… - Magnetic resonance …, 2015 - Elsevier
In the current management of acute ischemic stroke (AIS), clinical criteria are used to
estimate the risk of hemorrhagic transformation (HT), which is a devastating early …

Partial volume effect compensation for improved reliability of quantitative blood–brain barrier permeability

S Taheri, R Sood - Magnetic resonance imaging, 2007 - Elsevier
INTRODUCTION: Blood–brain barrier (BBB) plays an important role in the pathophysiology
of many central nervous system disorders. In the past, a number of laboratory techniques …

Measurement of brain perfusion, blood volume, and blood‐brain barrier permeability, using dynamic contrast‐enhanced T1‐weighted MRI at 3 tesla

HBW Larsson, F Courivaud, E Rostrup… - … in Medicine: An …, 2009 - Wiley Online Library
Assessment of vascular properties is essential to diagnosis and follow‐up and basic
understanding of pathogenesis in brain tumors. In this study, a procedure is presented that …

Measurement of blood‐brain barrier permeability using dynamic contrast‐enhanced magnetic resonance imaging with reduced scan time

J Bae, J Zhang, YZ Wadghiri, AS Minhas… - Magnetic resonance …, 2018 - Wiley Online Library
Purpose To investigate the feasibility of measuring the subtle disruption of blood‐brain
barrier (BBB) using DCE‐MRI with a scan duration shorter than 10 min. Methods The …

Accurate Determination of Blood–Brain Barrier Permeability Using Dynamic Contrast-Enhanced T1-Weighted MRI: A Simulation and in vivo Study on Healthy …

SP Cramer, HBW Larsson - Journal of Cerebral Blood Flow & …, 2014 - journals.sagepub.com
Dynamic contrast-enhanced magnetic resonance imaging (DCE–MRI) is increasingly used
to estimate permeability in situations with subtle blood–brain barrier (BBB) leakage …