BACKGROUND AND PURPOSE: The detailed mechanisms of cerebral aneurysm
generation remain unclear. Our aim was to investigate whether specific hemodynamic insult …

To determine whether arterial wall degeneration, in combination with hemodynamic insult,
causes cerebral artery aneurysms in a dog model, we simulated the geometry and …

Background and Purpose—Hemodynamic insults at arterial bifurcations are hypothesized to
play a key role in intracranial aneurysm formation. This study investigates aneurysm …

Background and Purpose—Arterial bifurcation apices are common sites for cerebral
aneurysms, raising the possibility that the unique hemodynamic conditions associated with …

PURPOSE: To develop a rabbit model of an intracranial bifurcation aneurysm to test new
endovascular therapies. MATERIALS AND METHODS: An experimental aneurysm model …

Prior studies, using systemic hypertension and elastase infusion, have induced cerebral
aneurysm (CA) formation in mice. However, the CAs induced were rapidly formed, relatively …

Background and Purpose The origin and pathogenesis of cerebral aneurysms arising at
nonbranching sites are not clear. Using our animal model to induce cerebral aneurysms in …

Background: Biological processes that lead to aneurysm formation, growth and rupture are
insufficiently understood. Vessel wall inflammation and degeneration are suggested to be …

BACKGROUND AND PURPOSE: Intracranial aneurysms have been induced in mice, rats,
rabbits, and primates through carotid artery ligation. We reviewed our experience with …

OBJECTIVE: Cerebral aneurysms are preferentially located at arterial bifurcation apices with
complex hemodynamics. To understand disease mechanisms associated with aneurysm …