Whole-brain N-acetylaspartate MR spectroscopic quantification: performance comparison of metabolite versus lipid nulling
JB Hövener, DJ Rigotti, M Amann… - American journal …, 2008 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Despite the prominent peak of N-acetylaspartate (NAA) in
proton MR spectroscopy (1H-MR spectroscopy) of the adult brain and its almost exclusive …
proton MR spectroscopy (1H-MR spectroscopy) of the adult brain and its almost exclusive …
Whole-brain N-acetylaspartate as a surrogate marker of neuronal damage in diffuse neurologic disorders
Proton MR spectroscopy (1H-MR spectroscopy) is a quantitative MR imaging technique
often used to complement the sensitivity of conventional MR imaging with specific metabolic …
often used to complement the sensitivity of conventional MR imaging with specific metabolic …
Total brain N‐acetylaspartate concentration in normal, age‐grouped females: Quantitation with non‐echo proton NMR spectroscopy
O Gonen, AK Viswanathan, I Catalaa… - Magnetic resonance …, 1998 - Wiley Online Library
The intra‐individual and inter‐individual variations of the global N‐acetylaspartate (NAA)
concentration were measured in a cohort of five 42±5 year‐old normal females. The total …
concentration were measured in a cohort of five 42±5 year‐old normal females. The total …
Absence of N‐acetylaspartate in the human brain: Impact on neurospectroscopy?
E Martin, A Capone, J Schneider, J Hennig… - Annals of …, 2001 - Wiley Online Library
N‐acetylaspartate (NAA) contributes to the most prominent signal in proton magnetic
resonance spectroscopy (1H‐MRS) of the adult human brain. We report the absence of NAA …
resonance spectroscopy (1H‐MRS) of the adult human brain. We report the absence of NAA …
Estimating NAA in cortical gray matter with applications for measuring changes due to aging
KO Lim, DM Spielman - Magnetic resonance in medicine, 1997 - Wiley Online Library
Abstract N‐acetylaspartic acid (NAA), a prominent peak in the proton spectrum, is an amino
acid thought to be present almost exclusively in neurons and their dendritic and axonal …
acid thought to be present almost exclusively in neurons and their dendritic and axonal …
Now it can be said: N-acetylaspartate IS a neuronal marker-a HRMAS proton MR spectroscopy and stereology study
With the ever increasing applications of in vivo MRS in clinical radiology, n-acetylaspartate
(NAA), as a widely used neuronal marker, has been playing an important role in diagnoses …
(NAA), as a widely used neuronal marker, has been playing an important role in diagnoses …
The accuracy of whole brain N-acetylaspartate quantification
O Gonen, RI Grossman - Magnetic resonance imaging, 2000 - Elsevier
A non-localizing pulse sequence to quantify the total amount of N-acetylaspartate (NAA) in
the whole brain (WBNAA) was introduced recently [Magn. Reson. Med. 40, 684–689 (1998)] …
the whole brain (WBNAA) was introduced recently [Magn. Reson. Med. 40, 684–689 (1998)] …
Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD
F Jessen, W Block, F Traber, E Keller, S Flacke… - Neurology, 2000 - AAN Enterprises
Background: The reduction of N-acetylaspartate (NAA) detected by proton MR spectroscopy
(1H-MRS) represents a robust but unspecific marker for neuronal loss or dysfunction …
(1H-MRS) represents a robust but unspecific marker for neuronal loss or dysfunction …
Reproducibility of the whole-brain N-acetylaspartate level across institutions, MR scanners, and field strengths
BACKGROUND AND PURPOSE: Radiologic markers in multicenter trials are often
confounded by different instrumentation used. Our goal was to estimate the variance of the …
confounded by different instrumentation used. Our goal was to estimate the variance of the …
Automated whole‐brain N‐acetylaspartate proton MRS quantification
Concentration of the neuronal marker, N‐acetylaspartate (NAA), a quantitative metric for the
health and density of neurons, is currently obtained by integration of the manually defined …
health and density of neurons, is currently obtained by integration of the manually defined …