Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging

JR Petrella, SE Prince, S Krishnan… - American journal …, 2009 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Cholinesterase-inhibitor therapy is approved for treatment
of Alzheimer disease; however, application in patients with mild cognitive impairment (MCI) …

Cortical activation during cholinesterase-inhibitor treatment in Alzheimer disease: preliminary findings from a pharmaco-fMRI study

TTJ Kircher, M Erb, W Grodd, DT Leube - The American journal of geriatric …, 2005 - Elsevier
Objective Cholinesterase inhibitors improve cognitive functioning in Alzheimer disease (AD).
The authors studied, with functional magnetic resonance imaging (fMRI), the neural …

Established donepezil treatment modulates regional brain activation in early Alzheimer's disease

WJ McGeown, MF Shanks… - Current Alzheimer …, 2010 - ingentaconnect.com
Neuroimaging studies of cholinesterase inhibitor (ChEI) treatment in Alzheimer's disease
(AD) have shown the different short and long term actions of ChEIs. fMRI studies of the ChEI …

Cholinergic enhancement of frontal lobe activity in mild cognitive impairment

AJ Saykin, HA Wishart, LA Rabin, LA Flashman… - Brain, 2004 - academic.oup.com
Cholinesterase inhibitors positively affect cognition in Alzheimer's disease (AD) and other
conditions, but no controlled functional MRI studies have examined where their effects occur …

Donepezil treatment stabilizes functional connectivity during resting state and brain activity during memory encoding in Alzheimer's disease

C Solé-Padullés, D Bartrés-Faz, A Lladó… - Journal of clinical …, 2013 - journals.lww.com
Previous studies with functional magnetic resonance imaging (fMRI) demonstrated a
differential brain activity and connectivity after treatment with donepezil in Alzheimer's …

An MRI substudy of a donepezil clinical trial in mild cognitive impairment

N Schuff, J Suhy, R Goldman, Y Xu, Y Sun… - Neurobiology of …, 2011 - Elsevier
A magnetic resonance imaging (MRI) study was conducted as part of an intervention study
in subjects with amnestic mild cognitive impairment (aMCI) to assess donepezil's treatment …

Treatment effects of therapeutic cholinesterase inhibitors on visuospatial processing in Alzheimer's disease: a longitudinal functional MRI study

SN Thiyagesh, TFD Farrow, RW Parks… - Dementia and geriatric …, 2010 - karger.com
Abstract Background/Aims: Visuospatial impairments are known to occur in Alzheimer's
disease (AD). We hypothesised that functional magnetic resonance imaging (fMRI) …

Donepezil effects on hippocampal and prefrontal functional connectivity in Alzheimer's disease: preliminary report

L Zaidel, G Allen, CM Cullum… - Journal of …, 2012 - content.iospress.com
We used functional connectivity magnetic resonance imaging (fcMRI) to investigate changes
in interhemispheric brain connectivity in 11 patients with mild Alzheimer's disease (AD) …

[HTML][HTML] Donepezil effects on cerebral blood flow in older adults with mild cognitive deficits

X Chen, VA Magnotta, K Duff… - The Journal of …, 2006 - Am Neuropsych Assoc
Cerebral blood flow (CBF) was assessed during a verbal recall task using [15O] water
positron emission tomography (PET) in older adults with mild cognitive deficits participating …

Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial

RS Doody, SH Ferris, S Salloway, Y Sun, R Goldman… - Neurology, 2009 - AAN Enterprises
Background: Treatment of mild cognitive impairment (MCI) with cholinesterase inhibitors
may improve symptoms. Methods: In this multicenter, randomized, placebo-controlled trial …