BACKGROUND AND PURPOSE: Recent studies have suggested that enhancing lesions on
contrast-enhanced T1-weighted MR images are predictive of impending exacerbations in …

Objective: The objective of this study was to assess if the presence of new lesions and their
topography on the reference MRI have a prognostic value regarding disease activity during …

BACKGROUND AND PURPOSE: Despite extensive use of MR imaging to provide markers
of multiple sclerosis (MS) activity and accumulated disease burden, the magnitude of the …

Background: Clinical intuition suggests that a sharp increase in the number of enhancing
lesions should signal an increased risk of relapse. The 'rule of five'recommends that subjects …

Objective: To generate and validate a composite (clinical and MRI-based) score able to
identify individual patients with relapsing-remitting multiple sclerosis (RRMS) with a high risk …

The aim of the study was to monitor the natural history of new enhancing lesions in multiple
sclerosis (MS) by means of serial gadolinium‐enhanced magnetic resonance imaging …

Background: Preliminary observational studies with multiple sclerosis (MS) patients have
reported strong correlations between an increase in hypointense lesion load (black holes) …

Relapses are the hallmark features of relapsing-remitting multiple sclerosis (RRMS). True
relapses may be challenging to accurately diagnose. A clinician must rely on a combination …

Background: The rate of new contrast-enhancing lesions (CELs) on monthly magnetic
resonance imaging (MRI) scans has been shown to decrease over a 9-month period in …

Magnetic resonance imaging (MRI) is the most important paraclinical test in the diagnosis of
multiple sclerosis (MS) and for delineating its natural history. We investigate MRIs from a …