Improved leakage correction for single-echo dynamic susceptibility contrast perfusion MRI estimates of relative cerebral blood volume in high-grade gliomas by …

K Leu, JL Boxerman, TF Cloughesy… - American Journal …, 2016 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Contrast agent extravasation through a disrupted blood-
brain barrier potentiates inaccurate DSC MR imaging estimation of relative CBV. We …

Effects of MRI protocol parameters, preload injection dose, fractionation strategies, and leakage correction algorithms on the fidelity of dynamic-susceptibility contrast …

K Leu, JL Boxerman… - American Journal of …, 2017 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: DSC perfusion MR imaging assumes that the contrast
agent remains intravascular; thus, disruptions in the blood-brain barrier common in brain …

Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not

JL Boxerman, KM Schmainda… - American Journal of …, 2006 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) estimates for high-
grade gliomas computed with dynamic susceptibility contrast MR imaging are artificially …

Bidirectional Contrast agent leakage correction of dynamic susceptibility contrast (DSC)‐MRI improves cerebral blood volume estimation and survival prediction in …

K Leu, JL Boxerman, A Lai… - Journal of Magnetic …, 2016 - Wiley Online Library
Purpose To evaluate a leakage correction algorithm for T1 and artifacts arising from contrast
agent extravasation in dynamic susceptibility contrast magnetic resonance imaging (DSC …

Impact of software modeling on the accuracy of perfusion MRI in glioma

LS Hu, Z Kelm, P Korfiatis, AC Dueck… - American Journal …, 2015 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Relative cerebral blood volume, as measured by T2*-
weighted dynamic susceptibility-weighted contrast-enhanced MRI, represents the most …

Consistency of normalized cerebral blood volume values in glioblastoma using different leakage correction algorithms on dynamic susceptibility contrast magnetic …

D Hedderich, A Kluge, T Pyka, C Zimmer… - Journal of …, 2019 - Elsevier
Background and purpose Several leakage correction algorithms for dynamic susceptibility
contrast (DSC) magnetic resonance imaging (MRI)-based cerebral blood volume (CBV) …

Characterizing the influence of preload dosing on percent signal recovery (PSR) and cerebral blood volume (CBV) measurements in a patient population with high …

LC Bell, LS Hu, AM Stokes, SC McGee, LC Baxter… - Tomography, 2017 - mdpi.com
With DSC-MRI, contrast agent leakage effects in brain tumors can either be leveraged for
percent signal recovery (PSR) measurements or be adequately resolved for accurate …

T1- and T*2-Dominant Extravasation Correction in DSC-MRI: Part I—Theoretical Considerations and Implications for Assessment of Tumor Hemodynamic Properties

A Bjornerud, AG Sorensen… - Journal of Cerebral …, 2011 - journals.sagepub.com
We present a novel contrast agent (CA) extravasation-correction method based on analysis
of the tissue residue function for assessment of multiple hemodynamic parameters. The …

Optimized preload leakage-correction methods to improve the diagnostic accuracy of dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging in …

LS Hu, LC Baxter, DS Pinnaduwage… - American Journal …, 2010 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) accuracy can vary
substantially depending on the dynamic susceptibility-weighted contrast-enhanced (DSC) …

Analysis of three leakage-correction methods for DSC-based measurement of relative cerebral blood volume with respect to heterogeneity in human gliomas

A Kluge, M Lukas, V Toth, T Pyka, C Zimmer… - Magnetic resonance …, 2016 - Elsevier
Purpose Aim of this study was to investigate the influence of contrast agent leakage on
relative cerebral blood volume (rCBV), using clinical dynamic susceptibility contrast (DSC) …