BACKGROUND AND PURPOSE: The pathogenesis of leukoaraiosis has long been
debated. This work addresses a less well-studied mechanism, cerebrovascular reactivity …

Purpose: To characterize multiple patterns of vascular changes in leukoaraiosis using in
vivo magnetic resonance imaging (MRI) techniques. Materials and Methods: We measured …

Background In spite of high prevalence and clinical relevance of leukoaraiosis (LA), its
pathophysiology is still incompletely understood. Theories of ischaemic genesis and a leaky …

Background: Ischemic leukoaraiosis (ILA) refers to diffuse T2-weighted white matter
hyperintensity in the context of a previous clinical lacunar stroke. Reduced cerebral blood …

Leukoaraiosis (LA) has been associated with abnormalities of both large and small blood
vessels. This study attempts to clarify the pathogenesis of LA by testing the hypothesis that …

The term'leukoaraiosis', derived from the Greek 'leuko'meaning white and 'araios' meaning
rarefied, was introduced in 1987, as a “neutral term, exact enough to define whitematter …

Abstract Introduction Quantitative MRI with T2, T2*, and T2′ mapping has been shown to
non-invasively depict microstructural changes (T2) and oxygenation status (T2* and T2′) …

OBJECTIVE White matter hypoperfusion may play a part in the pathogenesis of ischaemic
leukoaraiosis, but demonstration of this requires a high resolution quantitative method of …

PURPOSE: To investigate vessel density changes with increasing age in three areas of the
brain and to correlate these changes with leukoaraiosis (LA) on the basis of magnetic …

Objective: We examined the relationship between the perfusion reserve as measured by
acetazolamide (ACZ)-challenge N-isopropyl-I-123-p-iodoamphetamine (IMP)-single-photon …