Discussion The anterior neuropore closes at approximately the 25th day of intrauterine life
(1). At this time, three distinct brain vesicles develop. The most rostral one is known as the …

The brain malformation in which the prosencephalon fails to divide into hemispheres and
cerebral lobes is termed alobar holoprosencephaly (arhinencephaly)(2). Almost all these …

Modern ultrasound imaging devices have increasingly allowed sophisticated prenatal
diagnoses of fetal disorders. Embryopathologic and ultrasound findings are reported in five …

The classification of malformations recognized under the heading'arhinencephaly'has
recently been revised. A generic term'holoprosencephaly'has been suggested (ref. 5). This …

Five cases are presented to demonstrate the computed tomographic (CT) spectrum of
holoprosencephaly. The classifications of alobar, semilobar, and lobar types A and B …

The alobar form of holoprosencephaly is characterised by a huge spherical ventricle
localized in the midline. The monoventricle communicates with a large occipital cyst, the" …

Holoprosencephaly is a brain anomaly of varying severity with associated extracranial,
symptomatic abnormalities in only a minority of cases. The class of brain defects known as …

A series of 10 consecutive cases of alobar holoprosencephaly is described. the disorder
was diagnosed prenatally by ultrasound according to two criteria:(1) a large central fluid …

Abnormalities of glial and mesenchymal elements were studied in six autopsy specimens of
alobar holopresencephaly by histopathological and immunohistochemical methods …

Abnormal architecture of the telencephalic cortex was studied in six autopsy specimens of
alobar holoprosencephaly by histopathological, electron microscopic and …