Tissue-Specific Imaging Is a Robust Methodology to Differentiate In Vivo T1 Black Holes with Advanced Multiple Sclerosis–Induced Damage
M Riva, VN Ikonomidou, JJ Ostuni… - American journal …, 2009 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Brains of patients with multiple sclerosis (MS)
characteristically have “black holes”(BHs), hypointense lesions on T1-weighted (T1W) spin …
characteristically have “black holes”(BHs), hypointense lesions on T1-weighted (T1W) spin …
Lesions by tissue specific imaging characterize multiple sclerosis patients with more advanced disease
F Bagnato, VN Ikonomidou… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: Cerebrospinal fluid tissue specific imaging (CSF-TSI), a newly implemented
magnetic resonance imaging (MRI) technique, allows visualization of a subset of chronic …
magnetic resonance imaging (MRI) technique, allows visualization of a subset of chronic …
The role of edema and demyelination in chronic T1 black holes: A quantitative magnetization transfer study
Purpose To use quantitative magnetization transfer imaging (qMTI) in an investigation of T1‐
weighted hypointensity observed in clinical magnetic resonance imaging (MRI) scans of …
weighted hypointensity observed in clinical magnetic resonance imaging (MRI) scans of …
T1-thresholds in black holes increase clinical-radiological correlation in multiple sclerosis patients
C Thaler, T Faizy, J Sedlacik, B Holst, JP Stellmann… - PLoS …, 2015 - journals.plos.org
Background Magnetic Resonance Imaging (MRI) is an established tool in diagnosing and
evaluating disease activity in Multiple Sclerosis (MS). While clinical-radiological correlations …
evaluating disease activity in Multiple Sclerosis (MS). While clinical-radiological correlations …
Multi-parametric MR assessment of T1 black holes in multiple sclerosis: Evidence that myelin loss is not greater in hypointense versus isointense T1 lesions
Background Chronic T 1 hypointense lesions in multiple sclerosis (MS) are areas of severe
tissue destruction. The purpose of this study was to compare total water content (WC) …
tissue destruction. The purpose of this study was to compare total water content (WC) …
Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years
F Bagnato, N Jeffries, ND Richert, RD Stone… - Brain, 2003 - academic.oup.com
T1 black holes (BHs) on MRIs may represent either areas of oedema or axonal loss in
patients with multiple sclerosis. BHs begin as contrast enhancing lesions (CELs) and evolve …
patients with multiple sclerosis. BHs begin as contrast enhancing lesions (CELs) and evolve …
Characterizing contrast-enhancing and re-enhancing lesions in multiple sclerosis
Z Campbell, D Sahm, K Donohue, J Jamison, M Davis… - Neurology, 2012 - AAN Enterprises
Objectives: In multiple sclerosis (MS), contrast-enhancing lesions (CELs) in T1-weighted
postcontrast MRI are considered markers of blood–brain barrier breakdown. It remains …
postcontrast MRI are considered markers of blood–brain barrier breakdown. It remains …
Intensity ratio to improve black hole assessment in multiple sclerosis
G Adusumilli, K Trinkaus, P Sun, S Lancia… - Multiple sclerosis and …, 2018 - Elsevier
Background Improved imaging methods are critical to assess neurodegeneration and
remyelination in multiple sclerosis. Chronic hypointensities observed on T1-weighted brain …
remyelination in multiple sclerosis. Chronic hypointensities observed on T1-weighted brain …
Contrast-enhanced MRI lesions during treatment with interferonβ-1b predict increase in T1 black hole volume in patients with relapsing-remitting multiple sclerosis
K Morgen, ALT Crawford, RD Stone… - Multiple Sclerosis …, 2005 - journals.sagepub.com
T1 black holes (BH) have been found to represent focal areas of substantial central nervous
system tissue damage in multiple sclerosis (MS) patients. We examined the development of …
system tissue damage in multiple sclerosis (MS) patients. We examined the development of …
Multiple Sclerosis: Pathogenesis and MR Imaging Features of T1 Hypointensities in Murine Model1
I Pirko, TK Nolan, SK Holland, AJ Johnson - Radiology, 2008 - pubs.rsna.org
Purpose: To prospectively determine how T1 hypointensities (T1 black holes) on brain
magnetic resonance (MR) images are generated by the immune system by using a Theiler …
magnetic resonance (MR) images are generated by the immune system by using a Theiler …
