Quantitative MRI in multiple sclerosis: from theory to application

M Tranfa, G Pontillo, M Petracca… - American Journal …, 2022 - Am Soc Neuroradiology
Quantitative MR imaging techniques allow evaluating different aspects of brain
microstructure, providing meaningful information about the pathophysiology of damage in …

[HTML][HTML] Clinical correlates of R1 relaxometry and magnetic susceptibility changes in multiple sclerosis: a multi-parameter quantitative MRI study of brain iron and …

G Pontillo, M Petracca, S Monti, M Quarantelli… - European …, 2023 - Springer
Objectives The clinical impact of brain microstructural abnormalities in multiple sclerosis
(MS) remains elusive. We aimed to characterize the topography of longitudinal relaxation …

Unraveling deep gray matter atrophy and iron and myelin changes in multiple sclerosis

G Pontillo, M Petracca, S Monti… - American Journal …, 2021 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Modifications of magnetic susceptibility have been
consistently demonstrated in the subcortical gray matter of MS patients, but some …

Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis

C Granziera, J Wuerfel, F Barkhof, M Calabrese… - Brain, 2021 - academic.oup.com
Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

T1‐and T2‐based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosis

M Neema, J Stankiewicz, A Arora… - Journal of …, 2007 - Wiley Online Library
Magnetic resonance imaging (MRI) has emerged as a powerful noninvasive tool to assist in
the diagnosis and monitoring of multiple sclerosis (MS). In addition, investigators have used …

Susceptibility‐sensitive MRI of multiple sclerosis lesions and the impact of normal‐appearing white matter changes

V Wiggermann, S Hametner… - NMR in …, 2017 - Wiley Online Library
Susceptibility‐sensitive magnetic resonance imaging (MRI) has gained importance in
multiple sclerosis (MS) research because of its versatility, high resolution and excellent …

Magnetic resonance imaging of multiple sclerosis

M Filippi, C Tortorella, M Rovaris - Journal of Neuroimaging, 2002 - Wiley Online Library
Although conventional magnetic resonance imaging (cMRI) is widely used for diagnosing
multiple sclerosis (MS) and monitoring disease activity and evolution, the correlation …

Multiple sclerosis and allied white matter diseases

M Filippi, MA Rocca - Neurological sciences, 2008 - Springer
Advanced magnetic resonance imaging (MRI) approaches are extensively used for the
assessment of central nervous system (CNS) damage in patients with multiple sclerosis …

Advanced structural and functional brain MRI in multiple sclerosis

A Giorgio, N De Stefano - Seminars in neurology, 2016 - thieme-connect.com
Conventional magnetic resonance imaging (MRI) of the central nervous system is crucial for
an early and reliable diagnosis and monitoring of patients with multiple sclerosis (MS). Focal …

Linking structural, metabolic and functional changes in multiple sclerosis

M Filippi - European Journal of Neurology, 2001 - Wiley Online Library
In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) has
markedly improved our ability to detect the macroscopic abnormalities of the brain and …