BACKGROUND AND PURPOSE: Hypothermia has been shown to be beneficial in the
setting of acute SCI. However, widespread use has been hindered by the need for systemic …

There is widespread interest in the use of hypothermia in the treatment of CNS injury. While
there is considerable experience in the use of cooling for a variety of brain pathologies …

Objective Spinal cord injury (SCI) is a catastrophic neurological event with no proven
treatments that protect against its consequences. Potential benefits of hypothermia in …

Spinal cord injury (SCI) can cause devastating motor, sensory, and autonomic deficits. The
treatment of acute SCI is aimed at preventing secondary injury and promoting neural repair …

This review paper investigates the history, efficacy, and administration of systemic and local
hypothermia for spinal cord injury (SCI). It summarizes the published experimental and …

Background: Both local and systemic hypothermia have been of interest for decades as
potential therapies for acute spinal cord injury (SCI). 1, 2 In 2007 the American Association …

In a number of interventions, it is desirable to be able to produce a rapid but readily
reversible change in spinal cord temperature (SCT) without altering general body …

BACKGROUND Although a number of neuroprotective strategies have been tested after
spinal cord injury (SCI), no treatments have been established as a standard of care …

In this review we briefly discuss animal experiments involving acute traumatic spinal cord
injury (SCI) and the need for larger animals in testing experimental therapies. This literature …

BACKGROUND CONTEXT: Interest in systemic and local hypothermia extends back over
many decades, and both have been investigated as potential neuroprotective interventions …