BACKGROUND AND PURPOSE: Cerebral white matter changes, termed leukoaraiosis (LA),
appearing as areas of increased signal intensity in T2-weighted MR images, are common in …

Background and Purpose—Information on the neuropathological changes underlying
ischemic leukoaraiosis is only available postmortem, and there are limited data on …

Purpose: To characterize multiple patterns of vascular changes in leukoaraiosis using in
vivo magnetic resonance imaging (MRI) techniques. Materials and Methods: We measured …

Background: We aimed to explore the relation between the microstructural integrity of white
matter using the technique of diffusion tensor imaging (DTI) and changes of cognition in …

Background: Cerebral small vessel disease is a common cause of vascular dementia. Both
discrete lacunar infarcts and more diffuse ischaemic changes, seen as confluent high signal …

Purpose To test whole brain apparent diffusion coefficient histogram analysis as an
alternative approach to visual score for the assessment of leukoaraiosis (LA). Materials and …

Background and Purpose—Leukoaraiosis is a radiological finding of uncertain
pathogenesis with bilateral patchy or diffuse areas of hyperintensity of the cerebral white …

FLAIR and diffusion-weighted MRI were obtained twice (mean interval 20±4 months) in 10
patients with leukoaraiosis. At follow-up, visual extension of leukoaraiosis was unchanged …

Patterns of leukoaraiosis were analyzed on both T2-weighted fast fluid-attenuated inversion-
recovery and 3D T1-weighted sequences in 23 community-dwelling older subjects with mild …

Background: Damage to white matter tracts, resulting in “cerebral disconnection,” may
underlie age-related cognitive decline. Methods: Using diffusion tensor MRI (DTI) to …