Measuring myelin repair and axonal loss with diffusion tensor imaging
BACKGROUND AND PURPOSE: DTI is an MR imaging measure of brain tissue integrity
and provides an attractive metric for use in neuroprotection clinical trials. The purpose of our …
and provides an attractive metric for use in neuroprotection clinical trials. The purpose of our …
Identifying the start of multiple sclerosis injury: a serial DTI study
D Ontaneda, K Sakaie, J Lin, X Wang… - Journal of …, 2014 - Wiley Online Library
ABSTRACT BACKGROUND The events leading up to the development of new multiple
sclerosis (MS) lesions on conventional imaging are unknown. The purpose of this study is to …
sclerosis (MS) lesions on conventional imaging are unknown. The purpose of this study is to …
Increased diffusivity in acute multiple sclerosis lesions predicts risk of black hole
Objective: Diffusion tensor imaging (DTI) quantifies Brownian motion of water within tissue.
Inflammation leads to tissue injury, resulting in increased diffusivity and decreased …
Inflammation leads to tissue injury, resulting in increased diffusivity and decreased …
Effect of natalizumab on conversion of gadolinium enhancing lesions to T1 hypointense lesions in relapsing multiple sclerosis
CM Dalton, KA Miszkiel, GJ Barker, DG MacManus… - Journal of …, 2004 - Springer
Background: Natalizumab, a humanized monoclonal anti-adhesion molecule antibody,
reduces the frequency of new gadolinium (Gd) enhancing lesions and relapses in multiple …
reduces the frequency of new gadolinium (Gd) enhancing lesions and relapses in multiple …
Imaging outcome measures of neuroprotection and repair in MS: a consensus statement from NAIMS
Objective To summarize current and emerging imaging techniques that can be used to
assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus …
assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus …
Diffusion tensor magnetic resonance imaging in multiple sclerosis
Objectives: To quantify, using diffusion tensor imaging (DTI), the tissue damage in lesions
and normal-appearing white matter (NAWM) from a large cohort of patients with MS and to …
and normal-appearing white matter (NAWM) from a large cohort of patients with MS and to …
Picturing multiple sclerosis: conventional and diffusion tensor imaging
RJ Fox - Seminars in neurology, 2008 - thieme-connect.com
Magnetic resonance imaging (MRI) has provided an unparalleled window into
understanding multiple sclerosis (MS). Through recognition of relatively specific …
understanding multiple sclerosis (MS). Through recognition of relatively specific …
Voxel-wise magnetization transfer imaging study of effects of natalizumab and IFNβ-1a in multiple sclerosis
R Zivadinov, MG Dwyer, S Hussein… - Multiple Sclerosis …, 2012 - journals.sagepub.com
Objective: To determine the effects of intravenous natalizumab and intramuscular interferon
beta-1a (IFNβ-1a) on the volume of white-matter (WM) lesions and normal appearing brain …
beta-1a (IFNβ-1a) on the volume of white-matter (WM) lesions and normal appearing brain …
Diffusion tensor imaging as a prognostic biomarker for motor recovery and rehabilitation after stroke
Purpose Despite improved acute treatment and new tools to facilitate recovery, most patients
have motor deficits after stroke, often causing disability. However, motor impairment varies …
have motor deficits after stroke, often causing disability. However, motor impairment varies …
T1 recovery is predominantly found in black holes and is associated with clinical improvement in patients with multiple sclerosis
C Thaler, TD Faizy, J Sedlacik, B Holst… - American Journal …, 2017 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Quantitative MR imaging parameters help to evaluate
disease progression in multiple sclerosis and increase correlation with clinical disability. We …
disease progression in multiple sclerosis and increase correlation with clinical disability. We …
