BACKGROUND AND PURPOSE: Malignant glioma is a highly infiltrative malignancy that
causes variable disruptions to the structure and function of the cerebrovasculature. While …

OBJECTIVE. Glioblastoma is an invasive primary brain malignancy that typically infiltrates
the surrounding tissue with malignant cells. It disrupts cerebral blood flow through a variety …

Purpose: Insufficient control of infiltrative glioblastoma (GBM) cells is a major cause of
treatment failure and tumor recurrence. Hence, detailed insights into pathophysiologic …

Knowledge about the topological and structural heterogeneity of the microvasculature is
important for diagnosis and monitoring of glioma. A vessel caliber and type-dependent …

Introduction The presence of peritumorally impaired blood oxygenation-level dependent
cerebrovascular reactivity (BOLD-CVR) has been unequivocally demonstrated in patients …

Glioblastoma multiforme is a primary brain tumor known for its rapid proliferation, diffuse
invasion, and prominent neovasculature and necrosis. This study explores the in vivo link …

BACKGROUND AND PURPOSE: Imaging methods are currently being optimized in an
attempt to assess and monitor angiogenesis in vivo. The purpose of this investigation was to …

Purpose Cerebral diffuse gliomas exhibit perilesional impaired cerebrovascular reactivity
(CVR), yet the degree of impairment as well as its full spatial extent in the brain remains …

Background Conventional MRI fails to detect regions of glioblastoma cell infiltration beyond
the contrast‐enhanced T1 solid tumor region, with infiltrating tumor cells often migrating …

Purpose To use perfusion and magnetic resonance (MR) spectroscopy to compare the
diffusion tensor imaging (DTI)‐defined invasive and noninvasive regions. Invasion of normal …