BACKGROUND AND PURPOSE: Brain iron dyshomeostasis is increasingly recognized as
an important contributor to neurodegeneration. Hereditary hemochromatosis is the most …

For the last century, there has been great physiological interest in brain iron and its role in
brain function and disease. It is well known that iron accumulates in the brain for people with …

Iron plays a key role in a number of brain cellular processes. However, abnormal brain iron
regulation correlates with a number of neurodegenerative diseases such as Parkinson's …

Measuring iron content in the brain has important implications for a number of
neurodegenerative diseases. Quantitative susceptibility mapping (QSM), derived from …

Deposition of iron in the brain is proposed to play a role in the pathophysiology of the normal
aging process and neurodegenerative diseases. Whereas iron is required for normal …

Magnetic resonance imaging (MRI) brain imaging at high field strengths can demonstrate
regions of high iron deposition in the brain.• Iron deposits are present in all normal adult …

Background Detection of brain-MRI T2/T2* gradient echo images (T2* GRE)-hypointensity
can be compatible with iron accumulation and leads to a differential diagnosis work-up …

Background and purpose Hereditary haemochromatosis (HH) is the most common inherited
disorder of systemic iron excess in Northern Europeans. Emerging evidence indicates that …

METHODS: Ten normal human subjects (ages 35-73) underwent test and retest MRI scans
approximately 10 minutes apart. T1 and gradient-echo images were used to segment 7 …

Purpose To investigate the relationship between transverse relaxation rates R2 and R2*, the
most frequently used surrogate markers for iron in brain tissue, and chemically determined …