BACKGROUND AND PURPOSE: Ketone bodies provide important alternate fuel for brain
metabolism, and their transport into the brain increases with prolonged fasting. During …

BACKGROUND AND PURPOSE: Subclinical cerebral edema occurs in many, if not most,
children with diabetic ketoacidosis (DKA) and may be an indicator of subtle brain injury …

BACKGROUND AND PURPOSE: The ketogenic diet, including both classic and modified
forms, is an alternative to antiepileptic medications used in the treatment of drug-resistant …

Ketones are known to constitute an important fraction of fuel for consumption by the brain,
with brain ketone content generally thought to be low. However, the recent observation of 1 …

Ketogenic diet (KD) is highly effective in controlling epileptic seizures in children. One of the
mechanisms postulated, the accumulation of ketone bodies, acetoacetate (AcAc) and/or …

Using R-β-[1-11C] hydroxybutyrate and positron emission tomography, we studied the effect
of acute hyperketonemia (range 0.7–1.7 μmol/ml) on cerebral ketone body utilization in six …

BACKGROUND AND PURPOSE: Ketogenic diets are being explored as a possible
treatment for several neurological diseases, but the physiologic impact on the brain is …

OBJECTIVE Cerebral edema is a life-threatening complication of diabetic ketoacidosis
(DKA) in children. Recent data suggest that cerebral hypoperfusion and activation of …

Aims Type 1 diabetes is a prevalent chronic disease in childhood with the commonest single
cause of death being cerebral oedema in the context of diabetic ketoacidosis (DKA). The …

Atypical resonances on proton magnetic resonance spectroscopy (MRS) examinations are
occasionally found in children undergoing a metabolic evaluation for neurological …