BACKGROUND AND PURPOSE: Diffusion tensor (DT) images can provide information
about the nature of white matter changes, including axonal loss and demyelination. We …

Diffusion tensor imaging (DTI) has shown poorer microstructural white matter integrity in
children with phenylketonuria (PKU), specifically decreases in mean diffusivity (MD), in …

Previous research has documented white matter abnormalities in the brains of individuals
with early-treated phenylketonuria (ETPKU). The majority of these past studies have relied …

A multimodal MR study including relaxometry, diffusion tensor imaging (DTI), and MR
spectroscopy was performed on patients with classical phenylketonuria (PKU) and matched …

Background Despite dietary intervention, individuals with early treated phenylketonuria
(ETPKU) could present neurocognitive deficits and white matter (WM) abnormalities. The …

Objective Phenylketonuria (PKU) is an autosomal recessive disorder whereby deficiencies
in phenylalanine metabolism cause progressive neurological dysfunction. Managing PKU is …

Despite increasing knowledge about the effects of phenylketonuria on brain structure and
function, it is uncertain whether white matter microstructure is affected and if it is linked to …

Previous studies have revealed white matter abnormalities in the brains of individuals with
phenylketonuria (PKU), but the microstructural nature of these abnormalities and their …

BACKGROUND AND PURPOSE: Diffusion tensor imaging measures the proton diffusivity
and preferential orientation of the diffusion tensor. X-linked adrenoleukodystrophy is a …

PURPOSE: To prospectively determine the relationship between serum phenylalanine
levels and apparent diffusion coefficient (ADC) values in the cerebral white matter of patients …