BACKGROUND AND PURPOSE: Cerebral blood flow (CBF) abnormalities are previously
demonstrated in white matter disease. A gradation of change may exist between patients …

BACKGROUND AND PURPOSE: White matter lesions of presumed ischemic origin are
associated with progressive cognitive impairment and impaired BBB function. Studying the …

Background and Purpose—Cerebral small-vessel disease and cerebral blood flow (CBF)
are interrelated. However, the direction of the relationship is unknown, and longitudinal …

Introduction Presence of white matter hyperintensity (WMH) on MRI is a marker of cerebral
small vessel disease and is associated with increased small vessel stroke and increased …

We aimed to investigate optimal perfusion thresholds defining ischemic core and penumbra
for hemispheric-cortical gray matter (GM) and subcortical white matter (WM). A total of 65 …

Objective: To compare the diffusion and perfusion MRI metrics of normal-appearing white
matter (NAWM) with and without impaired cerebrovascular reactivity (CVR). Methods …

Background and Purpose—Increased blood–brain barrier (BBB) permeability occurs in
cerebral small vessel disease. It is not known if BBB changes predate progression of small …

White matter hyperintensities accumulate with age and occur in patients with stroke, but their
pathogenesis is poorly understood. We measured multiple magnetic resonance imaging …

The purpose of this study was to investigate whether low cerebral blood flow (CBF) is
associated with subsequent development of white matter hyperintensities (WMH). Patients …

Background and Purpose—CT perfusion (CTP) is widely and rapidly accessible for imaging
acute ischemic stroke but has limited validation. Cerebral blood volume (CBV) has been …