BACKGROUND AND PURPOSE: Frontotemporal lobar degeneration is responsible for the
cognitive abnormalities seen in patients with ALS. We sought to evaluate the in vivo …

Introduction Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative
disorder primarily affecting upper and lower motor neurons. Due to relative fast progression …

BACKGROUND AND PURPOSE: In the search for a diagnostic test for amyotrophic lateral
sclerosis (ALS), especially upper motor neuron (UMN) involvement, MR imaging and proton …

Background We investigated cerebral degeneration and neurochemistry in patients with
amyotrophic lateral sclerosis (ALS) using magnetic resonance spectroscopy (MRS) …

A major hurdle in the development of effective treatments for amyotrophic lateral sclerosis
(ALS) has been the lack of robust biomarkers for use as clinical trial endpoints …

Biomarkers beyond clinical assessment are needed in patients who suffer from amyotrophic
lateral sclerosis (ALS). Here, single-voxel proton magnetic resonance spectroscopy (1 H …

In vivo proton magnetic resonance spectroscopy (MRS) may be used to quantify brainstem
neuronal degeneration in ALS because of the neuronal localization of N-acetylaspartate and …

BACKGROUND AND PURPOSE: Various lines of evidence implicate cerebral involvement
beyond the motor cortex in ALS, including the cingulate gyrus and the thalamus. The …

Proton magnetic resonance spectroscopy (MRS) provides a means of measuring cerebral
metabolites relevant to neurodegeneration in vivo. In amyotrophic lateral sclerosis (ALS) …

Our objective was to assess and compare the diagnostic sensitivity of conventional MRI
(cMRI), magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI), and proton …