BACKGROUND AND PURPOSE: Total brain volume and total intracranial volume are
important measures for assessing whole-brain atrophy in Alzheimer disease, dementia, and …

Automated brain segmentation methods with a good precision and accuracy are required to
detect subtle changes in brain volumes over time in clinical applications. However, the …

Total intracranial volume (TIV/ICV) is an important covariate for volumetric analyses of the
brain and brain regions, especially in the study of neurodegenerative diseases, where it can …

Introduction Automated brain MRI morphometry, including hippocampal volumetry for
Alzheimer disease, is increasingly recognized as a biomarker. Consequently, a rapidly …

Volume and change in volume of the hippocampus are both important markers of
Alzheimer's disease (AD). Delineation of the structure on MRI is time-consuming and …

Introduction Pooling of multicenter brain imaging data is a trend in studies on ageing related
brain diseases. This poses challenges to MR-based brain segmentation. The performance …

Objective The aim of this study was to validate computed tomography (CT)-based
longitudinal markers of the progression of Alzheimer disease (AD). Materials and methods …

Background The change in volume of anatomic structures is as a sensitive indicator of
Alzheimer disease (AD) progression. Although several methods are available to measure …

BACKGROUND AND PURPOSE: MR-based volumetric measures of cerebral structures are
increasingly used for diagnostic purposes and to measure progression of atrophy. Variations …

Current semiautomated magnetic resonance (MR)-based brain segmentation and volume
measurement methods are complex and not sufficiently accurate for certain applications. We …