BACKGROUND AND PURPOSE: Recent flow dynamics studies have shown that the
eccentricity of the spinal cord affects the magnitude and characteristics of the slow bulk …

Clinical studies have shown that drugs delivered intrathecally distribute much faster than
can be accounted for by pure molecular diffusion. However, drug transport inside the …

Background Developing novel therapeutic agents to treat amyotrophic lateral sclerosis
(ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal …

We studied relationships of cerebral spinal fluid (CSF) pulsatile flow at cervical, thoracic, and
lumbar levels using phase-contrast cine MRI (PCCMRI) to determine the following: 1) …

Introduction Cerebrospinal fluid (CSF) absorption has long been held to predominantly
entail drainage into the venous outflow system via the intracranial arachnoid granulations …

BACKGROUND AND PURPOSE: Forced respirations reportedly have an effect on CSF
movement in the spinal canal. We studied respiratory-related CSF motion during normal …

The fluid that resides within cranial and spinal cavities, cerebrospinal fluid (CSF), moves in a
pulsatile fashion to and from the cranial cavity. This motion can be measured by magnetic …

Background: Traditionally, there is a widely held belief that drug dispersion after intrathecal
(IT) delivery is confined locally near the injection site. We posit that high-volume infusions …

1. Drugs injected into the lumbar space in a low-volume/low-rate paradigm will have an
action largely limited to the spinal regions proximal to the site of delivery. Increasing the …

This article provides an overview of magnetic resonance imaging (MRI) techniques used to
assess cerebrospinal fluid (CSF) movement in the central nervous system (CNS), including …