White Matter Alterations in Spastic Paraplegia Type 5: A Multiparametric Structural MRI Study and Correlations with Biochemical Measurements
Y Liu, Z Ye, J Hu, Z Xiao, F Zhang… - American Journal …, 2022 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: In spastic paraplegia type 5, spinal cord atrophy and white
matter signal abnormalities in the brain are the main MR imaging alterations. However, the …
matter signal abnormalities in the brain are the main MR imaging alterations. However, the …
Brain white matter involvement in hereditary spastic paraplegias: analysis with multiple diffusion tensor indices
G Aghakhanyan, A Martinuzzi, F Frijia… - American Journal …, 2014 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The hereditary spastic paraplegias are a group of
genetically heterogeneous neurodegenerative disorders, characterized by progressive …
genetically heterogeneous neurodegenerative disorders, characterized by progressive …
[HTML][HTML] Ascending axonal degeneration of the corticospinal tract in pure hereditary spastic paraplegia: a cross-sectional DTI study
Objective: To identify structural white matter alterations in patients with pure hereditary
spastic paraplegia (HSP) using high angular resolution diffusion tensor imaging (DTI) …
spastic paraplegia (HSP) using high angular resolution diffusion tensor imaging (DTI) …
Spinal cord gray and white matter damage in different hereditary spastic paraplegia subtypes
KR Servelhere, RF Casseb… - American Journal …, 2021 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Spinal cord damage is a hallmark of hereditary spastic
paraplegias, but it is still not clear whether specific subtypes of the disease have distinctive …
paraplegias, but it is still not clear whether specific subtypes of the disease have distinctive …
Hereditary spastic paraplegia: beyond clinical phenotypes toward a unified pattern of central nervous system damage
F Agosta, M Scarlato, EG Spinelli, E Canu, S Benedetti… - Radiology, 2015 - pubs.rsna.org
Purpose To investigate whether specific patterns of brain gray matter (GM) regional volumes
and white matter (WM) microstructural abnormalities and spinal cord atrophy occur in …
and white matter (WM) microstructural abnormalities and spinal cord atrophy occur in …
Tract-specific damage at spinal cord level in pure hereditary spastic paraplegia type 4: a diffusion tensor imaging study
Background SPG4 is a subtype of hereditary spastic paraplegia (HSP), an upper motor
neuron disorder characterized by axonal degeneration of the corticospinal tracts and the …
neuron disorder characterized by axonal degeneration of the corticospinal tracts and the …
MRI of autosomal dominant pure spastic paraplegia
K Krabbe, JE Nielsen, E Fallentin, K Fenger, M Herning - Neuroradiology, 1997 - Springer
We examined 16 patients with autosomal dominant pure spastic paraplegia (HSP) and 15
normal controls matched for age and sex using MRI of the brain and spinal cord. Images …
normal controls matched for age and sex using MRI of the brain and spinal cord. Images …
[HTML][HTML] Neuroimaging in hereditary spastic paraplegias: current use and future perspectives
FF Da Graca, TJR De Rezende… - Frontiers in …, 2019 - frontiersin.org
Hereditary spastic paraplegias (HSP) are a large group of genetic diseases characterized by
progressive degeneration of the long tracts of the spinal cord, namely the corticospinal tracts …
progressive degeneration of the long tracts of the spinal cord, namely the corticospinal tracts …
Diffusion tensor imaging in SPG11- and SPG4-linked hereditary spastic paraplegia
F Garaci, N Toschi, S Lanzafame… - International Journal …, 2014 - Taylor & Francis
The aim of this study was to identify potential diagnostic markers of Hereditary Spastic
Paraplegia (HSP). We investigated the white matter features of spastic gait (SPG) 11-and …
Paraplegia (HSP). We investigated the white matter features of spastic gait (SPG) 11-and …
Structural and metabolic damage in brains of patients with SPG11-related spastic paraplegia as detected by quantitative MRI
ML Stromillo, A Malandrini, MT Dotti, M Battaglini… - Journal of …, 2011 - Springer
The goal of this work was to assess brain structural and metabolic abnormalities of subjects
with SPG11 and their relevance to clinical disability by using quantitative magnetic …
with SPG11 and their relevance to clinical disability by using quantitative magnetic …