BACKGROUND AND PURPOSE: The role of juxtacortical lesions in brain volume loss in
multiple sclerosis has not been fully clarified. The aim of this study was to explore the role of …

BACKGROUND AND PURPOSE: We assessed whether the extent of macro-and
microscopic disease in the cortical and subcortical brain tissue, as revealed by MR and …

Background: Accurate classification of multiple sclerosis (MS) lesions in the brain cortex may
be important in understanding their impact on cognitive impairment (CI). Improved accuracy …

Objective This study aimed to investigate at 7.0-T MRI a) the role of multiple sclerosis (MS)
cortical lesions in cortical tissue loss b) their relation to neurological disability. Methods In 76 …

Background: Recent pathologic investigations have shown that neocortical lesions are
frequent in multiple sclerosis (MS). Structural MRI has shown that neocortical atrophy occurs …

Cortical and subcortical atrophy occurs in multiple sclerosis (MS) and relates to clinical
outcomes. FreeSurfer, a voxel-based automated software for brain reconstruction was used …

Objective It has been suggested recently that cortical pathology in multiple sclerosis (MS)
may, at least partly, be caused by factors in cerebrospinal fluid (CSF). We thus hypothesized …

Background Recent studies suggest that cortical lesions in multiple sclerosis (MS)
substantially contribute to clinical disease severity. The present study aimed at investigating …

Forty–one patients with multiple sclerosis were studied with magnetic resonance imaging
(MRI) and a battery of neuropsychological tests to determine the pattern of lobar distribution …

Understanding the importance of cortical lesions in MS pathogenesis has changed.
Histopathologic studies using new immunohistochemical methods show that cortical lesions …