MRI Surrogates for Molecular Subgroups of Medulloblastoma
Abstract
BACKGROUND AND PURPOSE: Recently identified molecular subgroups of medulloblastoma have shown potential for improved risk stratification. We hypothesized that distinct MR imaging features can predict these subgroups.
MATERIALS AND METHODS: All patients with a diagnosis of medulloblastoma at one institution, with both pretherapy MR imaging and surgical tissue, served as the discovery cohort (n = 47). MR imaging features were assessed by 3 blinded neuroradiologists. NanoString-based assay of tumor tissues was conducted to classify the tumors into the 4 established molecular subgroups (wingless, sonic hedgehog, group 3, and group 4). A second pediatric medulloblastoma cohort (n = 52) from an independent institution was used for validation of the MR imaging features predictive of the molecular subtypes.
RESULTS: Logistic regression analysis within the discovery cohort revealed tumor location (P < .001) and enhancement pattern (P = .001) to be significant predictors of medulloblastoma subgroups. Stereospecific computational analyses confirmed that group 3 and 4 tumors predominated within the midline fourth ventricle (100%, P = .007), wingless tumors were localized to the cerebellar peduncle/cerebellopontine angle cistern with a positive predictive value of 100% (95% CI, 30%–100%), and sonic hedgehog tumors arose in the cerebellar hemispheres with a positive predictive value of 100% (95% CI, 59%–100%). Midline group 4 tumors presented with minimal/no enhancement with a positive predictive value of 91% (95% CI, 59%–98%). When we used the MR imaging feature–based regression model, 66% of medulloblastomas were correctly predicted in the discovery cohort, and 65%, in the validation cohort.
CONCLUSIONS: Tumor location and enhancement pattern were predictive of molecular subgroups of pediatric medulloblastoma and may potentially serve as a surrogate for genomic testing.
Abbreviations
- CP/CPA
- cerebellar peduncle/cerebellopontine angle cistern
- FSL
- fMRI of the Brain Software Library
- SHH
- sonic hedgehog
- WNT
- wingless
Footnotes
Yoon-Jae Cho and Kristen W. Yeom are co-senior authors.
- © 2014 American Society of Neuroradiology
Indicates open access to non-subscribers at www.ajnr.org
Jump to section
Related Articles
Cited By...
- MR Imaging of Pediatric Low-Grade Gliomas: Pretherapeutic Differentiation of BRAF V600E Mutation, BRAF Fusion, and Wild-Type Tumors in Patients without Neurofibromatosis-1
- Anatomic Neuroimaging Characteristics of Posterior Fossa Type A Ependymoma Subgroups
- Radiomic Phenotypes Distinguish Atypical Teratoid/Rhabdoid Tumors from Medulloblastoma
- A Diagnostic Algorithm for Posterior Fossa Tumors in Children: A Validation Study
- Radiomics of Pediatric Low-Grade Gliomas: Toward a Pretherapeutic Differentiation of BRAF-Mutated and BRAF-Fused Tumors
- New Approaches in Targeted Therapy for Medulloblastoma in Children
- MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma
- MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial
- Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort
- MR Imaging-Based Radiomic Signatures of Distinct Molecular Subgroups of Medulloblastoma
- MRI Characteristics of Primary Tumors and Metastatic Lesions in Molecular Subgroups of Pediatric Medulloblastoma: A Single-Center Study
- Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation
- Multiparametric Analysis of Permeability and ADC Histogram Metrics for Classification of Pediatric Brain Tumors by Tumor Grade
- Imaging Biomarkers for Adult Medulloblastomas: Genetic Entities May Be Identified by Their MR Imaging Radiophenotype
- Molecular mechanisms and therapeutic targets in pediatric brain tumors
- MR Imaging Characteristics of Wingless-Type-Subgroup Pediatric Medulloblastoma
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Costas D. Arvanitis, Gino B. Ferraro, Rakesh K. JainNature Reviews Cancer 2020 20 1
- Ketty Leto, Marife Arancillo, Esther B. E. Becker, Annalisa Buffo, Chin Chiang, Baojin Ding, William B. Dobyns, Isabelle Dusart, Parthiv Haldipur, Mary E. Hatten, Mikio Hoshino, Alexandra L. Joyner, Masanobu Kano, Daniel L. Kilpatrick, Noriyuki Koibuchi, Silvia Marino, Salvador Martinez, Kathleen J. Millen, Thomas O. Millner, Takaki Miyata, Elena Parmigiani, Karl Schilling, Gabriella Sekerková, Roy V. Sillitoe, Constantino Sotelo, Naofumi Uesaka, Annika Wefers, Richard J. T. Wingate, Richard HawkesThe Cerebellum 2016 15 6
- Eric M Thompson, Thomas Hielscher, Eric Bouffet, Marc Remke, Betty Luu, Sridharan Gururangan, Roger E McLendon, Darell D Bigner, Eric S Lipp, Sebastien Perreault, Yoon-Jae Cho, Gerald Grant, Seung-Ki Kim, Ji Yeoun Lee, Amulya A Nageswara Rao, Caterina Giannini, Kay Ka Wai Li, Ho-Keung Ng, Yu Yao, Toshihiro Kumabe, Teiji Tominaga, Wieslawa A Grajkowska, Marta Perek-Polnik, David C Y Low, Wan Tew Seow, Kenneth T E Chang, Jaume Mora, Ian F Pollack, Ronald L Hamilton, Sarah Leary, Andrew S Moore, Wendy J Ingram, Andrew R Hallahan, Anne Jouvet, Michelle Fèvre-Montange, Alexandre Vasiljevic, Cecile Faure-Conter, Tomoko Shofuda, Naoki Kagawa, Naoya Hashimoto, Nada Jabado, Alexander G Weil, Tenzin Gayden, Takafumi Wataya, Tarek Shalaby, Michael Grotzer, Karel Zitterbart, Jaroslav Sterba, Leos Kren, Tibor Hortobágyi, Almos Klekner, Bognár László, Tímea Pócza, Peter Hauser, Ulrich Schüller, Shin Jung, Woo-Youl Jang, Pim J French, Johan M Kros, Marie-Lise C van Veelen, Luca Massimi, Jeffrey R Leonard, Joshua B Rubin, Rajeev Vibhakar, Lola B Chambless, Michael K Cooper, Reid C Thompson, Claudia C Faria, Alice Carvalho, Sofia Nunes, José Pimentel, Xing Fan, Karin M Muraszko, Enrique López-Aguilar, David Lyden, Livia Garzia, David J H Shih, Noriyuki Kijima, Christian Schneider, Jennifer Adamski, Paul A Northcott, Marcel Kool, David T W Jones, Jennifer A Chan, Ana Nikolic, Maria Luisa Garre, Erwin G Van Meir, Satoru Osuka, Jeffrey J Olson, Arman Jahangiri, Brandyn A Castro, Nalin Gupta, William A Weiss, Iska Moxon-Emre, Donald J Mabbott, Alvaro Lassaletta, Cynthia E Hawkins, Uri Tabori, James Drake, Abhaya Kulkarni, Peter Dirks, James T Rutka, Andrey Korshunov, Stefan M Pfister, Roger J Packer, Vijay Ramaswamy, Michael D TaylorThe Lancet Oncology 2016 17 4
- Timothy N. Phoenix, Deanna M. Patmore, Scott Boop, Nidal Boulos, Megan O. Jacus, Yogesh T. Patel, Martine F. Roussel, David Finkelstein, Liliana Goumnerova, Sebastien Perreault, Elizabeth Wadhwa, Yoon-Jae Cho, Clinton F. Stewart, Richard J. GilbertsonCancer Cell 2016 29 4
- Kyle Juraschka, Michael D. TaylorJournal of Neurosurgery: Pediatrics 2019 24 4
- Vijay Ramaswamy, Michael D. TaylorJournal of Clinical Oncology 2017 35 21
- Maura Massimino, Veronica Biassoni, Lorenza Gandola, Maria Luisa Garrè, Gemma Gatta, Felice Giangaspero, Geraldina Poggi, Stefan RutkowskiCritical Reviews in Oncology/Hematology 2016 105
- Derek R. Johnson, Julie B. Guerin, Caterina Giannini, Jonathan M. Morris, Lawrence J. Eckel, Timothy J. KaufmannRadioGraphics 2017 37 7
- M. Iv, M. Zhou, K. Shpanskaya, S. Perreault, Z. Wang, E. Tranvinh, B. Lanzman, S. Vajapeyam, N.A. Vitanza, P.G. Fisher, Y.J. Cho, S. Laughlin, V. Ramaswamy, M.D. Taylor, S.H. Cheshier, G.A. Grant, T. Young Poussaint, O. Gevaert, K.W. YeomAmerican Journal of Neuroradiology 2019 40 1