Abstract
SUMMARY: Magnetic particle imaging is an emerging tomographic technique with the potential for simultaneous high-resolution, high-sensitivity, and real-time imaging. Magnetic particle imaging is based on the unique behavior of superparamagnetic iron oxide nanoparticles modeled by the Langevin theory, with the ability to track and quantify nanoparticle concentrations without tissue background noise. It is a promising new imaging technique for multiple applications, including vascular and perfusion imaging, oncology imaging, cell tracking, inflammation imaging, and trauma imaging. In particular, many neuroimaging applications may be enabled and enhanced with magnetic particle imaging. In this review, we will provide an overview of magnetic particle imaging principles and implementation, current applications, promising neuroimaging applications, and practical considerations.
ABBREVIATIONS:
- FFL
- field-free line
- FFP
- field-free point
- FFR
- field-free region
- MPI
- magnetic particle imaging
- SPIO
- superparamagnetic iron oxide
- SPION
- superparamagnetic iron oxide nanoparticle
Footnotes
Disclosures: Gary Steinberg—UNRELATED: Royalties: Peter Lazic US; Stock/Stock Options: Qool Therapeutics, NeuroSave, Comments: stock options only from both companies. Tim Doyle—UNRELATED: Payment for Lectures Including Service on Speakers Bureaus: Magnetic Insight, Comments: talk presented at a magnetic particle imaging workshop at the 2017 World Molecular Imaging Congress (Philadelphia). Honorarium was paid. Steven Conolly—UNRELATED: Grants/Grants Pending: National Institutes of Health, University of California, Office of the President.* Max Wintermark—UNRELATED: Board Membership: GE NFL Advisory Board; Stock/Stock Options: MORE Health, Icometrix; Other: Equity, Comments: Magnetic Insight. Kannan Krishnan—UNRELATED: Grant: University of Washington.* *Money paid to the institution.
- © 2019 by American Journal of Neuroradiology
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